Dual-wavelength photothermal optical coherence tomography for imaging microvasculature blood oxygen saturation

Biwei Yin, Roman V. Kuranov, Austin B. McElroy, Shams Kazmi, Andrew K. Dunn, Timothy Q. Duong, Thomas E. Milner

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

A swept-source dual-wavelength photothermal (DWP) optical coherence tomography (OCT) system is demonstrated for quantitative imaging of microvasculature oxygen saturation. DWP-OCT is capable of recording three-dimensional images of tissue and depth-resolved phase variation in response to photothermal excitation. A 1,064-nm OCT probe and 770-nm and 800-nm photothermal excitation beams are combined in a single-mode optical fiber to measure microvasculature hemoglobin oxygen saturation (SO2) levels in phantom blood vessels with a range of blood flow speeds (0 to 17 mm/s). A 50-μm-diameter blood vessel phantom is imaged, and SO2 levels are measured using DWP-OCT and compared with values provided by a commercial oximeter at various blood oxygen concentrations. The influences of blood flow speed and mechanisms of SNR phase degradation on the accuracy of SO2 measurement are identified and investigated.

Original languageEnglish (US)
Article number056005
JournalJournal of Biomedical Optics
Volume18
Issue number5
DOIs
StatePublished - May 1 2013

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Keywords

  • dual-wavelength
  • hemoglobin oxygen saturation
  • imaging
  • microvasculature
  • optical coherence tomography
  • phantom
  • phase-sensitive

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

Cite this

Yin, B., Kuranov, R. V., McElroy, A. B., Kazmi, S., Dunn, A. K., Duong, T. Q., & Milner, T. E. (2013). Dual-wavelength photothermal optical coherence tomography for imaging microvasculature blood oxygen saturation. Journal of Biomedical Optics, 18(5), [056005]. https://doi.org/10.1117/1.JBO.18.5.056005