Dual radiolabeled liposomes: Biodistribution studies and localization of focal sites of infection in rats

V. D. Awasthi, Beth Goins, Robert Klipper, William T. Phillips

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Liposomes encapsulating both glutathione and deferoxamine were labeled with 99mTc-HMPAO and 111In-oxine at the same time. These dual radiolabeled liposomes were intravenously injected in rats with S. aureus infection in thigh. The target-to-background ratio (T/BG) increased from 2.9 at 2 h to 4.4 at 8 h in 99mTc images. In 111In images, T/BG of 5.5 at 8 h increased to 10.5 by 48 h. The 24-h spleen uptake of 111In- and 99mTc-liposomes was 24.14%ID and 8.91%ID. In femur, 99mTc-liposomes remained at ~10.5%ID, but 111In-liposomes increased from ~11%ID at 4 h to ~25.5%ID at 24 h. The simultaneous presence of 99mTc and 111In in the liposomes resulted in good early (2-8 h) as well as delayed (24-48 h) images delineating the infection site.

Original languageEnglish (US)
Pages (from-to)155-160
Number of pages6
JournalNuclear Medicine and Biology
Volume25
Issue number2
DOIs
StatePublished - Feb 1998

Keywords

  • Dual radiolabeled liposomes
  • In-liposomes
  • Infection imaging
  • Long circulating liposomes
  • Tc-liposomes

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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