Dual-modality fiber-based OCT-TPL imaging system for simultaneous microstructural and molecular analysis of atherosclerotic plaques

Tianyi Wang, Austin McElroy, David Halaney, Deborah Vela, Edmund Fung, Shafat Hossain, Jennifer Phipps, Bingqing Wang, Biwei Yin, Marc D. Feldman, Thomas E. Milner

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

New optical imaging techniques that provide contrast to study both the anatomy and composition of atherosclerotic plaques can be utilized to better understand the formation, progression and clinical complications of human coronary artery disease. We present a dual-modality fiber-based optical imaging system for simultaneous microstructural and molecular analysis of atherosclerotic plaques that combines optical coherence tomography (OCT) and two-photon luminescence (TPL) imaging. Experimental results from ex vivo human coronary arteries show that OCT and TPL optical contrast in recorded OCT-TPL images is complimentary and in agreement with histological analysis. Molecular composition (e.g., lipid and oxidized-LDL) detected by TPL imaging can be overlaid onto plaque microstructure depicted by OCT, providing new opportunities for atherosclerotic plaque identification and characterization.

Original languageEnglish (US)
Article numberA009
Pages (from-to)1665-1678
Number of pages14
JournalBiomedical Optics Express
Volume6
Issue number5
DOIs
StatePublished - Apr 10 2015

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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