D1-dopamine receptor activation mediates [3H]acetylcholine release from rabbit retina

J. G. Hensler, M. L. Dubocovich

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Dopamine and dopamine receptor agonists (0.1 μM-10 mM) evoked, in a concentration-dependent manner, calcium-dependent release of [3H]acetylcholine from the rabbit retina labeled in vitro with [3H]choline. This stimulatory effect of dopamine was antagonized by SCH 23390 and by α-flupenthixol, but not by S-sulpiride or propranolol. Increases in intracellular cyclic AMP by forskolin, 3-isobutyl-1-methylxanthine and 8-bromo-cyclic AMP also evoked calcium-dependent release of [3H]acetylcholine. These results indicate that activation of a receptor with the biochemical and pharmacological characteristics of a D1-dopamine receptor mediates calcium-dependent release of acetylcholine from rabbit retina, possibly through a cyclic AMP-dependent process.

Original languageEnglish (US)
Pages (from-to)407-412
Number of pages6
JournalBrain Research
Volume398
Issue number2
DOIs
StatePublished - Nov 29 1986

Keywords

  • D-dopamine receptor
  • Rabbit retina
  • SCH 23390
  • SKF 38398
  • SKF 82526
  • [H]Acetylcholine release

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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