Dry powder inhalation for pulmonary delivery: Recent advances and continuing challenges

Simone R. Carvalho, Alan B. Watts, Jay I. Peters, Robert O. Williams

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Abstract

The pulmonary route of administration is used to treat respiratory and systemic diseases and has gained increasing importance in the field of drug delivery due to its unique advantages including targeted delivery, improved convenience, and rapid onset. In light of some remarkable improvements in the development of dry powder inhaler (DPI) devices and formulations over the last few years, there continues to be a need for further optimized DPI systems. Recently, researchers have focused on finding ways to enhance dry powder inhalation therapy by improving the physicochemical characteristics of the powder formulation and optimizing the device performance. The aim of this chapter is to review the most recent advances in DPI technology. Accordingly, we provide a review of the most recent reported improvements in DPI design, mechanisms of powder dispersion, dry powder composition, and delivery and characterization methods for DPI products.

Original languageEnglish (US)
Title of host publicationPulmonary Drug Delivery
Subtitle of host publicationAdvances and Challenges
Publisherwiley
Pages35-62
Number of pages28
ISBN (Electronic)9781118799536
ISBN (Print)9781118799529; 9781118799505; 9781118799482; 9781118799543
DOIs
StatePublished - Jan 1 2015

Keywords

  • Aerodynamic size distribution
  • Computational fluid dynamics
  • Delivered-dose uniformity
  • Dry powder inhaler devices
  • Powder dispersion
  • Pulmonary delivery
  • Spray drying

ASJC Scopus subject areas

  • Chemistry(all)

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