Drug-reinforced responding: rapid determination of dose-response functions

G. Winger, R. K. Palmer, J. H. Woods

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Rhesus monkeys were conditioned to press on levers and receive intravenous infusions of cocaine or ketamine. Experimental conditions provided several different doses of drug during each of two daily 130 min sessions; as a result, a doseresponse curve relating rate of responding to dose/injection for self-administered drug was obtained within each session. Relative rate-maintaining effects of nomifensine and cocaine in monkeys on baseline conditions of cocaine self-administration, and rate-maintaining effects of ketamine, phencyclidine and MK-801 in monkeys on baseline conditions of ketamine self-administration, compared favorably with relative rate-maintaining effects of these substances obtained in more traditional paradigms.

Original languageEnglish (US)
Pages (from-to)135-142
Number of pages8
JournalDrug and Alcohol Dependence
Volume24
Issue number2
DOIs
StatePublished - Oct 1989
Externally publishedYes

Keywords

  • MK-801
  • cocaine
  • ketamine
  • nomifensine
  • phencyclidine
  • rhesus monkeys
  • self-administration

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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