Drug-reinforced responding: rapid determination of dose-response functions

G. Winger; R. K. Palmer; J. H. Woods

doi:10.1016/0376-8716(89)90076-8

Drug-reinforced responding: rapid determination of dose-response functions

G. Winger, R. K. Palmer, J. H. Woods

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Rhesus monkeys were conditioned to press on levers and receive intravenous infusions of cocaine or ketamine. Experimental conditions provided several different doses of drug during each of two daily 130 min sessions; as a result, a doseresponse curve relating rate of responding to dose/injection for self-administered drug was obtained within each session. Relative rate-maintaining effects of nomifensine and cocaine in monkeys on baseline conditions of cocaine self-administration, and rate-maintaining effects of ketamine, phencyclidine and MK-801 in monkeys on baseline conditions of ketamine self-administration, compared favorably with relative rate-maintaining effects of these substances obtained in more traditional paradigms.

Original language	English (US)
Pages (from-to)	135-142
Number of pages	8
Journal	Drug and Alcohol Dependence
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/0376-8716(89)90076-8
State	Published - Oct 1989
Externally published	Yes

Keywords

MK-801
cocaine
ketamine
nomifensine
phencyclidine
rhesus monkeys
self-administration

ASJC Scopus subject areas

Toxicology
Pharmacology
Psychiatry and Mental health
Pharmacology (medical)

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10.1016/0376-8716(89)90076-8

Cite this

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title = "Drug-reinforced responding: rapid determination of dose-response functions",

abstract = "Rhesus monkeys were conditioned to press on levers and receive intravenous infusions of cocaine or ketamine. Experimental conditions provided several different doses of drug during each of two daily 130 min sessions; as a result, a doseresponse curve relating rate of responding to dose/injection for self-administered drug was obtained within each session. Relative rate-maintaining effects of nomifensine and cocaine in monkeys on baseline conditions of cocaine self-administration, and rate-maintaining effects of ketamine, phencyclidine and MK-801 in monkeys on baseline conditions of ketamine self-administration, compared favorably with relative rate-maintaining effects of these substances obtained in more traditional paradigms.",

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AU - Winger, G.

AU - Palmer, R. K.

AU - Woods, J. H.

N1 - Funding Information: Work was supported by Public Health Service Grants DA 05325a nd DA 04403.T echnical

PY - 1989/10

Y1 - 1989/10

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KW - MK-801

KW - cocaine

KW - ketamine

KW - nomifensine

KW - phencyclidine

KW - rhesus monkeys

KW - self-administration

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Drug-reinforced responding: rapid determination of dose-response functions

Abstract

Keywords

ASJC Scopus subject areas

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