Drug Interactions in Hypertensive Patients: Pharmacokinetic, Pharmacodynamic and Genetic Considerations

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Abstract

Antihypertensive treatment has proven benefits, and the number of patients being treated with these drugs is significant. Hypertensive patients may have other medical illnesses for which they receive medications, and interactions between antihypertensive agents and other drugs is likely. Some of these interactions may lead to undesirable effects or even loss of blood pressure control. However, drug interactions can also be beneficial when 2 antihypertensive drugs with different pharmacological actions are prescribed in combination and with a clear therapeutic objective in mind. Clinicians should be aware of the mechanisms and the consequences of the different types of interaction in hypertensive patients, so that a desired pharmacological response can be achieved with the fewest side effects in the patients.

Original languageEnglish (US)
Pages (from-to)295-317
Number of pages23
JournalClinical Pharmacokinetics
Volume18
Issue number4
DOIs
StatePublished - Apr 1990

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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