Drug delivery from therapeutic self-assembled monolayers (T-SAMs) on 316L stainless steel

Anil Mahapatro, Dave M. Johnson, Devang N. Patel, Marc D Feldman, Arturo A. Ayon, C. Mauli Agrawal

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Delivery of therapeutic agents from self-assembled monolayers (SAMs) on 316L stainless steel (SS) has been demonstrated as a viable method to deliver drugs for localized coronary artery stent application. SAMs are highly-ordered, nano-sized molecular coatings, adding 1-10 nm thickness to a surface. Hydroxyl terminated alkanethiol SAMs of 11-mercapto-1-undecanol (-OH SAM) were formed on 316L SS with 48 hr immersion in ethanolic solutions. Attachment of ibuprofen (a model drug) to the functional SAMs was carried out in toluene for 5 hrs at 60°C using Novozume-435 as a biocatalyst. SAM formation and subsequent attachment of ibuprofen was characterized collectively using X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), and contact angle (CA) measurements. The quantitative in vitro release of ibuprofen into a "physiological" buffer solution was characterized using reverse phase HPLC. Drug release kinetics showed that 14.1 μg of ibuprofen eluted over a period of 35 days with 2.7μg being eluted in the first day and the remaining being eluted over a period of 35 days. The drug release kinetics showed an increase in ibuprofen elution that occurred during first 14 days (2.7μg in 1 day to 9.5 μg in 14 days), following which there was a decrease in the rate of elution. Thus, functional SAMs on 316L SS could be used as tethers for drug attachment and could serve as a drug delivery mechanism from stainless steel implants such as coronary artery stents.

Original languageEnglish (US)
Pages (from-to)281-289
Number of pages9
JournalCurrent Topics in Medicinal Chemistry
Volume8
Issue number4
DOIs
StatePublished - Mar 2008

Fingerprint

Ibuprofen
Stainless Steel
Self assembled monolayers
Drug delivery
Pharmaceutical Preparations
Stents
Coronary Vessels
Pharmacokinetics
Therapeutics
Photoelectron Spectroscopy
Toluene
Immersion
Fourier Transform Infrared Spectroscopy
Hydroxyl Radical
Kinetics
Buffers
Angle measurement
High Pressure Liquid Chromatography
Contact angle
X ray photoelectron spectroscopy

Keywords

  • 316 L SS
  • Drug delivery
  • Self assembled monolayers
  • Stent

ASJC Scopus subject areas

  • Medicine(all)
  • Chemistry(all)

Cite this

Drug delivery from therapeutic self-assembled monolayers (T-SAMs) on 316L stainless steel. / Mahapatro, Anil; Johnson, Dave M.; Patel, Devang N.; Feldman, Marc D; Ayon, Arturo A.; Agrawal, C. Mauli.

In: Current Topics in Medicinal Chemistry, Vol. 8, No. 4, 03.2008, p. 281-289.

Research output: Contribution to journalArticle

Mahapatro, Anil ; Johnson, Dave M. ; Patel, Devang N. ; Feldman, Marc D ; Ayon, Arturo A. ; Agrawal, C. Mauli. / Drug delivery from therapeutic self-assembled monolayers (T-SAMs) on 316L stainless steel. In: Current Topics in Medicinal Chemistry. 2008 ; Vol. 8, No. 4. pp. 281-289.
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