Drug delivery from therapeutic self-assembled monolayers (T-SAMs) on 316L stainless steel

Anil Mahapatro, Dave M. Johnson, Devang N. Patel, Marc D. Feldman, Arturo A. Ayon, C. Mauli Agrawal

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

Delivery of therapeutic agents from self-assembled monolayers (SAMs) on 316L stainless steel (SS) has been demonstrated as a viable method to deliver drugs for localized coronary artery stent application. SAMs are highly-ordered, nano-sized molecular coatings, adding 1-10 nm thickness to a surface. Hydroxyl terminated alkanethiol SAMs of 11-mercapto-1-undecanol (-OH SAM) were formed on 316L SS with 48 hr immersion in ethanolic solutions. Attachment of ibuprofen (a model drug) to the functional SAMs was carried out in toluene for 5 hrs at 60°C using Novozume-435 as a biocatalyst. SAM formation and subsequent attachment of ibuprofen was characterized collectively using X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), and contact angle (CA) measurements. The quantitative in vitro release of ibuprofen into a "physiological" buffer solution was characterized using reverse phase HPLC. Drug release kinetics showed that 14.1 μg of ibuprofen eluted over a period of 35 days with 2.7μg being eluted in the first day and the remaining being eluted over a period of 35 days. The drug release kinetics showed an increase in ibuprofen elution that occurred during first 14 days (2.7μg in 1 day to 9.5 μg in 14 days), following which there was a decrease in the rate of elution. Thus, functional SAMs on 316L SS could be used as tethers for drug attachment and could serve as a drug delivery mechanism from stainless steel implants such as coronary artery stents.

Original languageEnglish (US)
Pages (from-to)281-289
Number of pages9
JournalCurrent topics in medicinal chemistry
Volume8
Issue number4
DOIs
StatePublished - Mar 1 2008

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Keywords

  • 316 L SS
  • Drug delivery
  • Self assembled monolayers
  • Stent

ASJC Scopus subject areas

  • Drug Discovery

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