Drug combinations in the treatment of refractory depression: A review

S. L. Stern, J. Mendels

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


The authors critically review several drug combinations that may be of promise in the management of depressions that do not respond to treatment with a single drug. These include the use of tricyclic antidepressants with monoamine oxidase inhibitors (MAOI's), L-triiodothyronine (T3), methylphenidate, lithium carbonate, L-tryptophan, reserpine, and neuroleptics; MAOI's with lithium and L-tryptophan; and L-tryptophan with alllopurinol. The authors stress the need for further double-blind controlled studies to evaluate the safety and efficacy of these combinations.

Original languageEnglish (US)
Pages (from-to)368-373
Number of pages6
JournalJournal of Clinical Psychiatry
Issue number10
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Psychiatry and Mental health


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