Drug combinations in the treatment of refractory depression: A review

S. L. Stern, J. Mendels

Research output: Contribution to journalReview article

23 Scopus citations


The authors critically review several drug combinations that may be of promise in the management of depressions that do not respond to treatment with a single drug. These include the use of tricyclic antidepressants with monoamine oxidase inhibitors (MAOI's), L-triiodothyronine (T3), methylphenidate, lithium carbonate, L-tryptophan, reserpine, and neuroleptics; MAOI's with lithium and L-tryptophan; and L-tryptophan with alllopurinol. The authors stress the need for further double-blind controlled studies to evaluate the safety and efficacy of these combinations.

Original languageEnglish (US)
Pages (from-to)368-373
Number of pages6
JournalJournal of Clinical Psychiatry
Issue number10
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Psychiatry and Mental health

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