Drinking sucrose enhances quinpirole-induced yawning in rats

Michelle G. Baladi, Amy H. Newman, Yvonne M. Thomas, Charles P. France

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Food and drugs can activate brain dopamine systems and sensitivity to the effects of drugs acting on those systems is influenced by amount and content of food consumed. This study examined the effects of drinking sucrose on behavioral effects of the direct-acting dopamine receptor agonist quinpirole. Male Sprague-Dawley rats (n=6/group) had free access to water or 10% sucrose and quinpirole dose-response curves (yawning and hypothermia) were generated weekly for 8 weeks. Subsequently, all rats drank water for 8 weeks with quinpirole dose-response curves determined on weeks 9, 10, and 16. In rats drinking sucrose, the ascending (D3 receptor-mediated), but not descending (D2 receptor-mediated), limb of the yawning dose-response curve shifted leftward. The D3 receptor-selective antagonist PG01037 shifted the ascending limb of the dose-response curve to the right in all rats. When rats that previously drank sucrose drank water, their sensitivity to quinpirole did not return to normal. Quinpirole-induced hypothermia was not different between groups. These data show that drinking sucrose increases sensitivity to a dopamine D3, but not D2, receptor-mediated effect and that this change is long lasting. Dopamine receptors mediate the effects of many drugs and the actions of those drugs are likely impacted by dietary factors.

Original languageEnglish (US)
Pages (from-to)773-778
Number of pages6
JournalBehavioural pharmacology
Issue number8
StatePublished - Dec 2011


  • dopamine receptor
  • hypothermia
  • quinpirole
  • rat
  • sucrose
  • yawning

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health


Dive into the research topics of 'Drinking sucrose enhances quinpirole-induced yawning in rats'. Together they form a unique fingerprint.

Cite this