Abstract
The haematopoietic homeobox gene Hex (also called Prh) is expressed in myeloid cells and B cells but not T cells. To investigate whether Hex levels might play a role in myeloid versus T-cell development, two types of transgenic mouse lines were constructed, each with ectopic expression of Her in T cells (CDIIa/Hex and Lck/Hex). Both these types of transgenic mouse had the same defects in T-cell maturation, indicating that proper T-cell development may be dependent not just on the up-regulation of lymphoid-specific transcriptional regulators but also on the co-ordinated down-regulation of myeloid-specific transcriptional regulators such as Hex. In addition, Hex over-expression significantly increased myeloid progenitor cycling, which may explain its role in retrovirally induced murine leukaemia.
Original language | English (US) |
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Pages (from-to) | 444-451 |
Number of pages | 8 |
Journal | Immunology |
Volume | 107 |
Issue number | 4 |
DOIs | |
State | Published - Dec 1 2002 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology