Double-blind detoxification of methadone maintenance patients

Jim Mintz, Charles P. O'brien, Kate O'hare, Jean Goldschmidt

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Twenty-four methadone maintenance patients were assigned to (1) decreasing dose (N = 12) or (2) continued methadone maintenance (N = 12), matching for dose, initial complaint levels, and counselor. After 14 weeks most patients in both groups had terminated from the study. Detoxifying patients usually terminated by obtaining a dose increase or dropping out; maintenance patients usually terminated for external reasons. Prior to terminating, detoxifying patients reported increased withdrawal complaints but no awareness doses had decreased. Termination was not directly related to dose level or percentage decrease. In both groups, terminators were likely to have been high in complaints during the baseline period

Original languageEnglish (US)
Pages (from-to)815-824
Number of pages10
JournalSubstance Use and Misuse
Issue number5
StatePublished - Jan 1 1975
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Health(social science)
  • Public Health, Environmental and Occupational Health
  • Psychiatry and Mental health


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