DOT1L: orchestrating methylation-dependent radiotheRAPy responses via BRCA1

Justin W. Leung; Kyle M. Miller

doi:10.1016/j.tips.2024.09.008

DOT1L: orchestrating methylation-dependent radiotheRAPy responses via BRCA1

Justin W. Leung
, Kyle M. Miller

Research output: Contribution to journal › Short survey › peer-review

Abstract

Breast Cancer Type 1 Susceptibility Protein (BRCA)-1 existing in several functionally distinct complexes, promotes DNA repair of DNA double-strand breaks (DSBs). A recent study by Tang and colleagues identifies the lysine methyltransferase Disruptor of Telomeric Silencing 1-Like (DOT1L) involved in modifying Receptor-Associated Protein 80 (RAP80) to promote BRCA1-A complex localization and repair functions at DNA breaks. This study illuminates a potential therapeutic target for cancer radiotherapy.

Original language	English (US)
Pages (from-to)	955-957
Number of pages	3
Journal	Trends in Pharmacological Sciences
Volume	45
Issue number	11
DOIs	https://doi.org/10.1016/j.tips.2024.09.008
State	Published - Nov 2024

Keywords

BRCA1
DOT1L
RAP80
homologous recombination
radiotherapy

ASJC Scopus subject areas

Toxicology
Pharmacology

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10.1016/j.tips.2024.09.008

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title = "DOT1L: orchestrating methylation-dependent radiotheRAPy responses via BRCA1",

abstract = "Breast Cancer Type 1 Susceptibility Protein (BRCA)-1 existing in several functionally distinct complexes, promotes DNA repair of DNA double-strand breaks (DSBs). A recent study by Tang and colleagues identifies the lysine methyltransferase Disruptor of Telomeric Silencing 1-Like (DOT1L) involved in modifying Receptor-Associated Protein 80 (RAP80) to promote BRCA1-A complex localization and repair functions at DNA breaks. This study illuminates a potential therapeutic target for cancer radiotherapy.",

keywords = "BRCA1, DOT1L, RAP80, homologous recombination, radiotherapy",

author = "Leung, \{Justin W.\} and Miller, \{Kyle M.\}",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Ltd",

year = "2024",

month = nov,

doi = "10.1016/j.tips.2024.09.008",

language = "English (US)",

volume = "45",

pages = "955--957",

journal = "Trends in Pharmacological Sciences",

issn = "0165-6147",

publisher = "Elsevier Ltd",

number = "11",

}

TY - JOUR

T1 - DOT1L

T2 - orchestrating methylation-dependent radiotheRAPy responses via BRCA1

AU - Leung, Justin W.

AU - Miller, Kyle M.

PY - 2024/11

Y1 - 2024/11

N2 - Breast Cancer Type 1 Susceptibility Protein (BRCA)-1 existing in several functionally distinct complexes, promotes DNA repair of DNA double-strand breaks (DSBs). A recent study by Tang and colleagues identifies the lysine methyltransferase Disruptor of Telomeric Silencing 1-Like (DOT1L) involved in modifying Receptor-Associated Protein 80 (RAP80) to promote BRCA1-A complex localization and repair functions at DNA breaks. This study illuminates a potential therapeutic target for cancer radiotherapy.

AB - Breast Cancer Type 1 Susceptibility Protein (BRCA)-1 existing in several functionally distinct complexes, promotes DNA repair of DNA double-strand breaks (DSBs). A recent study by Tang and colleagues identifies the lysine methyltransferase Disruptor of Telomeric Silencing 1-Like (DOT1L) involved in modifying Receptor-Associated Protein 80 (RAP80) to promote BRCA1-A complex localization and repair functions at DNA breaks. This study illuminates a potential therapeutic target for cancer radiotherapy.

KW - BRCA1

KW - DOT1L

KW - RAP80

KW - homologous recombination

KW - radiotherapy

UR - https://www.scopus.com/pages/publications/85205781482

UR - https://www.scopus.com/pages/publications/85205781482#tab=citedBy

U2 - 10.1016/j.tips.2024.09.008

DO - 10.1016/j.tips.2024.09.008

M3 - Short survey

C2 - 39389815

AN - SCOPUS:85205781482

SN - 0165-6147

VL - 45

SP - 955

EP - 957

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

IS - 11

ER -

DOT1L: orchestrating methylation-dependent radiotheRAPy responses via BRCA1

Abstract

Keywords

ASJC Scopus subject areas

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