Dosing of contrast material to prevent contrast nephropathy in patients with renal disease

Ricardo G. Cigarroa, Richard A. Lange, Russel H. Williams, David Hillis

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402 Scopus citations


purpose; Contrast-induced renal dysfunction has been reported to occur in 15% to 42% of patients with underlying azotemia, but there is disagreement as to whether its incidence is reduced by limiting the amount of contrast material. To adjust the amount of contrast material to the severity of azotemia, we have utilized the following formula to calculate a contrast material "limit" in patients with renal disease:. Contrast material limit = 5 mL of contrast/kg body weight (maximum, 300 mL) serum creatinine (mg/dL). patients and methods: Over a 10-year period, 115 patients (53 men, 62 women, aged 61 ± 11 [mean ± SD] years) with renal dysfunction (baseline serum creatinine level greater than or equal to 1.8 mg/dL) underwent cardiac catherization and angiography, after which the level serum creatinine was measured daily for five days. The amount of contrast material that was given adhered to the limit in 86 patients (Group I) and exceeded it in 29 (Group II). results: Contrast-induced renal dysfunction (an increase in serum creatinine greater than or equal to 1.0 mg/dL) occurred in two (2%) patients in Group I and in six (21%) patients in Group II (p <0.001). Of the 48 patients with concomitant diabetes mellitus, the contrast limit was surpassed in 16, six (38%) of whom had contrast nephropathy. Only two of the 32 (6%) diabetic patients in whom the contrast limit was not exceeded had contrast nephropathy (p <0.001). conclusions: Thus, contrast-induced renal dysfunction occurs infrequently if the amount of contrast material is limited in accordance with the degree of azotemia. Diabetic patients have a high incidence of contrast nephropathy, particularly when they receive an excessive amount of contrast. In patients with diabetes and renal impairment, it may be preferable to perform angiography as a staged procedure or to utilize alternative (non-contrast) techniques to obtain the desired information rather than to exceed the prescribed contrast limit.

Original languageEnglish (US)
Pages (from-to)649-652
Number of pages4
JournalThe American Journal of Medicine
Issue number6 C
StatePublished - 1989

ASJC Scopus subject areas

  • Medicine(all)


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