Dosimetric evaluation of a Monte Carlo IMRT treatment planning system incorporating the MIMiC

P. Rassiah-Szegedi, M. Fuss, D. Sheikh-Bagheri, M. Szegedi, Sotirios Stathakis, Jack L Lancaster, Nikos Papanikolaou, B. Salter

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The high dose per fraction delivered to lung lesions in stereotactic body radiation therapy (SBRT) demands high dose calculation and delivery accuracy. The inhomogeneous density in the thoracic region along with the small fields used typically in intensity-modulated radiation therapy (IMRT) treatments poses a challenge in the accuracy of dose calculation. In this study we dosimetrically evaluated a pre-release version of a Monte Carlo planning system (PEREGRINE 1.6b, NOMOS Corp., Cranberry Township, PA), which incorporates the modeling of serial tomotherapy IMRT treatments with the binary multileaf intensity modulating collimator (MIMiC). The aim of this study is to show the validation process of PEREGRINE 1.6b since it was used as a benchmark to investigate the accuracy of doses calculated by a finite size pencil beam (FSPB) algorithm for lung lesions treated on the SBRT dose regime via serial tomotherapy in our previous study. Doses calculated by PEREGRINE were compared against measurements in homogeneous and inhomogeneous materials carried out on a Varian 600C with a 6 MV photon beam. Phantom studies simulating various sized lesions were also carried out to explain some of the large dose discrepancies seen in the dose calculations with small lesions. Doses calculated by PEREGRINE agreed to within 2% in water and up to 3% for measurements in an inhomogeneous phantom containing lung, bone and unit density tissue.

Original languageEnglish (US)
Pages (from-to)6931-6941
Number of pages11
JournalPhysics in Medicine and Biology
Volume52
Issue number23
DOIs
StatePublished - Dec 7 2007

Fingerprint

Radiotherapy
collimators
planning
radiation therapy
Dosimetry
Planning
dosage
evaluation
Lung
lesions
Vaccinium macrocarpon
Benchmarking
lungs
Therapeutics
Photons
Bone Density
Bone
Thorax
Tissue
bone mineral content

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physics and Astronomy (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Rassiah-Szegedi, P., Fuss, M., Sheikh-Bagheri, D., Szegedi, M., Stathakis, S., Lancaster, J. L., ... Salter, B. (2007). Dosimetric evaluation of a Monte Carlo IMRT treatment planning system incorporating the MIMiC. Physics in Medicine and Biology, 52(23), 6931-6941. https://doi.org/10.1088/0031-9155/52/23/011

Dosimetric evaluation of a Monte Carlo IMRT treatment planning system incorporating the MIMiC. / Rassiah-Szegedi, P.; Fuss, M.; Sheikh-Bagheri, D.; Szegedi, M.; Stathakis, Sotirios; Lancaster, Jack L; Papanikolaou, Nikos; Salter, B.

In: Physics in Medicine and Biology, Vol. 52, No. 23, 07.12.2007, p. 6931-6941.

Research output: Contribution to journalArticle

Rassiah-Szegedi, P, Fuss, M, Sheikh-Bagheri, D, Szegedi, M, Stathakis, S, Lancaster, JL, Papanikolaou, N & Salter, B 2007, 'Dosimetric evaluation of a Monte Carlo IMRT treatment planning system incorporating the MIMiC', Physics in Medicine and Biology, vol. 52, no. 23, pp. 6931-6941. https://doi.org/10.1088/0031-9155/52/23/011
Rassiah-Szegedi P, Fuss M, Sheikh-Bagheri D, Szegedi M, Stathakis S, Lancaster JL et al. Dosimetric evaluation of a Monte Carlo IMRT treatment planning system incorporating the MIMiC. Physics in Medicine and Biology. 2007 Dec 7;52(23):6931-6941. https://doi.org/10.1088/0031-9155/52/23/011
Rassiah-Szegedi, P. ; Fuss, M. ; Sheikh-Bagheri, D. ; Szegedi, M. ; Stathakis, Sotirios ; Lancaster, Jack L ; Papanikolaou, Nikos ; Salter, B. / Dosimetric evaluation of a Monte Carlo IMRT treatment planning system incorporating the MIMiC. In: Physics in Medicine and Biology. 2007 ; Vol. 52, No. 23. pp. 6931-6941.
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