Dosimetric comparison of volumetric modulated Arc therapy, step-and-shoot, and sliding window IMRT for prostate cancer

Erich Schnell, Tania De La Fuente Herman, Julie Young, Kim Hildebrand, Ozer Algan, Elizabeth Syzek, Terence Herman, Salahuddin Ahmad

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

This study aims to evaluate treatment plans generated by Step-and-Shoot (SS), Sliding Window (SW) and Volumetric Modulated Arc Therapy (VMAT) in order to assess the differences in dose volume histograms of planning target volume (PTV) and organs at risk (OAR), conformity indices, radiobiological evaluations, and plan quality for prostate cancer cases. Six prostate cancer patients treated in our center were selected for this retrospective study. Treatment plans were generated with Eclipse version 8.9 using 10 MV photon beams. For VMAT, Varian Rapid Arc with 1 or 2 arcs, and for SS and SW IMRT, 7-9 fields were used. Each plan had three PTVs with prescription doses of 81, 59.4, and 45 Gy to prostate, to prostate and lymph nodes, and to pelvis, respectively. Doses to PTV and OAR and the conformal indices (COIN) were compared among three techniques. The equivalent uniform dose (EUD), tumor control probability (TCP) and normal tissue complication probability (NTCP) were calculated and compared. The mean doses to the PTV prostate on average were 83 Gy and the percent differences of mean dose among all techniques were below 0.28. For bladder and rectum, the percent differences of mean dose among all techniques were below 2.2. The COIN did not favour any particular delivery method over the other. The TCP was higher with SS and SW for four patients and higher with VMAT for two patients. The NTCP for the rectum was the lowest with VMAT in five out of the six patients. The results show similar target coverage in general.

Original languageEnglish (US)
Title of host publicationMedical Physics - Twelfth Mexican Symposium on Medical Physics
Pages23-26
Number of pages4
DOIs
StatePublished - 2012
Externally publishedYes
Event12th Mexican Symposium on Medical Physics - Oaxaca, Mexico
Duration: Mar 16 2012Mar 19 2012

Publication series

NameAIP Conference Proceedings
Volume1494
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference12th Mexican Symposium on Medical Physics
Country/TerritoryMexico
CityOaxaca
Period3/16/123/19/12

Keywords

  • Intensity Modulated Radiation Therapy
  • Prostate Cancer
  • Sliding Window
  • Step and Shoot
  • Volumetric Modulated Arc Therapy

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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