Dosimetric and radiobiologic comparison of 3D conformal, IMRT, VMAT and proton therapy for the treatment of early-stage glottic cancer

Chance Matthiesen; Tania De La Fuente Herman; Hardev Singh; Anthony Mascia; Michael Confer; Hilarie Simpson; Christine Higby; Abeer Arain; Sameer Keole; Terence Herman; Carl Bogardus; Yan D. Zhao; Salahuddin Ahmad

doi:10.1111/1754-9485.12227

Dosimetric and radiobiologic comparison of 3D conformal, IMRT, VMAT and proton therapy for the treatment of early-stage glottic cancer

Chance Matthiesen, Tania De La Fuente Herman, Hardev Singh, Anthony Mascia, Michael Confer, Hilarie Simpson, Christine Higby, Abeer Arain, Sameer Keole, Terence Herman, Carl Bogardus, Yan D. Zhao, Salahuddin Ahmad

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19 Scopus citations

Abstract

Background This study aims to compare dosimetrically and radiobiologically 3D conformal, intensity modulated radiation therapy (IMRT), RapidArc (RA) volumetric modulated arc therapy and proton therapy techniques for early-stage glottic cancer. Methods Ten patients were retrospectively selected. Photon treatment planning was performed using Eclipse External Beam Planning, and proton planning was performed using CMS Xio. The minimum, mean and maximum dose values for planning target volume (PTV), mean and maximum dose values for organ at risk, % of volume of PTV receiving at least 95% of the prescription dose, and D20, D50 and D90 of carotid arteries were compared. Biological response models of tumour control probabilities and normal tissue complication probabilities were calculated. Results IMRT, RA and proton plans versus three-dimensional conformal radiotherapy (3D-CRT) plans consistently provided superior PTV coverage and decreased mean dose to the thyroid and carotid arteries. Conclusion All these three modalities showed superiority with less variation among themselves compared with 3D-CRT plans. Clinical investigation is warranted to determine if these treatment approaches will translate into a reduction in radiation therapy-induced toxicities.

Original language	English (US)
Pages (from-to)	221-228
Number of pages	8
Journal	Journal of Medical Imaging and Radiation Oncology
Volume	59
Issue number	2
DOIs	https://doi.org/10.1111/1754-9485.12227
State	Published - Apr 1 2015
Externally published	Yes

Keywords

head and neck cancer
IMRT
larynx cancer
proton therapy
radiotherapy

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging

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10.1111/1754-9485.12227

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Matthiesen, C., Herman, T. D. L. F., Singh, H., Mascia, A., Confer, M., Simpson, H., Higby, C., Arain, A., Keole, S., Herman, T., Bogardus, C., Zhao, Y. D., & Ahmad, S. (2015). Dosimetric and radiobiologic comparison of 3D conformal, IMRT, VMAT and proton therapy for the treatment of early-stage glottic cancer. Journal of Medical Imaging and Radiation Oncology, 59(2), 221-228. https://doi.org/10.1111/1754-9485.12227

Matthiesen, C, Herman, TDLF, Singh, H, Mascia, A, Confer, M, Simpson, H, Higby, C, Arain, A, Keole, S, Herman, T, Bogardus, C, Zhao, YD & Ahmad, S 2015, 'Dosimetric and radiobiologic comparison of 3D conformal, IMRT, VMAT and proton therapy for the treatment of early-stage glottic cancer', Journal of Medical Imaging and Radiation Oncology, vol. 59, no. 2, pp. 221-228. https://doi.org/10.1111/1754-9485.12227

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abstract = "Background This study aims to compare dosimetrically and radiobiologically 3D conformal, intensity modulated radiation therapy (IMRT), RapidArc (RA) volumetric modulated arc therapy and proton therapy techniques for early-stage glottic cancer. Methods Ten patients were retrospectively selected. Photon treatment planning was performed using Eclipse External Beam Planning, and proton planning was performed using CMS Xio. The minimum, mean and maximum dose values for planning target volume (PTV), mean and maximum dose values for organ at risk, % of volume of PTV receiving at least 95% of the prescription dose, and D20, D50 and D90 of carotid arteries were compared. Biological response models of tumour control probabilities and normal tissue complication probabilities were calculated. Results IMRT, RA and proton plans versus three-dimensional conformal radiotherapy (3D-CRT) plans consistently provided superior PTV coverage and decreased mean dose to the thyroid and carotid arteries. Conclusion All these three modalities showed superiority with less variation among themselves compared with 3D-CRT plans. Clinical investigation is warranted to determine if these treatment approaches will translate into a reduction in radiation therapy-induced toxicities.",

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author = "Chance Matthiesen and Herman, {Tania De La Fuente} and Hardev Singh and Anthony Mascia and Michael Confer and Hilarie Simpson and Christine Higby and Abeer Arain and Sameer Keole and Terence Herman and Carl Bogardus and Zhao, {Yan D.} and Salahuddin Ahmad",

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AU - Matthiesen, Chance

AU - Herman, Tania De La Fuente

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AU - Mascia, Anthony

AU - Confer, Michael

AU - Simpson, Hilarie

AU - Higby, Christine

AU - Arain, Abeer

AU - Keole, Sameer

AU - Herman, Terence

AU - Bogardus, Carl

AU - Zhao, Yan D.

AU - Ahmad, Salahuddin

PY - 2015/4/1

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N2 - Background This study aims to compare dosimetrically and radiobiologically 3D conformal, intensity modulated radiation therapy (IMRT), RapidArc (RA) volumetric modulated arc therapy and proton therapy techniques for early-stage glottic cancer. Methods Ten patients were retrospectively selected. Photon treatment planning was performed using Eclipse External Beam Planning, and proton planning was performed using CMS Xio. The minimum, mean and maximum dose values for planning target volume (PTV), mean and maximum dose values for organ at risk, % of volume of PTV receiving at least 95% of the prescription dose, and D20, D50 and D90 of carotid arteries were compared. Biological response models of tumour control probabilities and normal tissue complication probabilities were calculated. Results IMRT, RA and proton plans versus three-dimensional conformal radiotherapy (3D-CRT) plans consistently provided superior PTV coverage and decreased mean dose to the thyroid and carotid arteries. Conclusion All these three modalities showed superiority with less variation among themselves compared with 3D-CRT plans. Clinical investigation is warranted to determine if these treatment approaches will translate into a reduction in radiation therapy-induced toxicities.

AB - Background This study aims to compare dosimetrically and radiobiologically 3D conformal, intensity modulated radiation therapy (IMRT), RapidArc (RA) volumetric modulated arc therapy and proton therapy techniques for early-stage glottic cancer. Methods Ten patients were retrospectively selected. Photon treatment planning was performed using Eclipse External Beam Planning, and proton planning was performed using CMS Xio. The minimum, mean and maximum dose values for planning target volume (PTV), mean and maximum dose values for organ at risk, % of volume of PTV receiving at least 95% of the prescription dose, and D20, D50 and D90 of carotid arteries were compared. Biological response models of tumour control probabilities and normal tissue complication probabilities were calculated. Results IMRT, RA and proton plans versus three-dimensional conformal radiotherapy (3D-CRT) plans consistently provided superior PTV coverage and decreased mean dose to the thyroid and carotid arteries. Conclusion All these three modalities showed superiority with less variation among themselves compared with 3D-CRT plans. Clinical investigation is warranted to determine if these treatment approaches will translate into a reduction in radiation therapy-induced toxicities.

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Dosimetric and radiobiologic comparison of 3D conformal, IMRT, VMAT and proton therapy for the treatment of early-stage glottic cancer

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Keywords

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