Dose-dependent prolactin releasing activity of arginine vasotocin in intact and pinealectomized estrogen-progesterone treated adult male rats

Mary K. Vaughan, David E. Blask, George M. Vaughan, Russel J. Reiter

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Abstract

Estrogen-progesterone (EP) treated adult male rats were injected intravenously (iv) with 0.1, 1 or 10 μg arginine vasotocin (AVT) or Ringers lactate solution. A significant dose-related rise in plasma prolactin was evident 10 min after injection with AVT. In a second experiment, shamoperated or pinealectomized EP-treated male rats were injected iv with 0.1 or 1 μg AVT or diluent. Plasma prolactin was significantly elevated in both sham-operated and pinealectomized groups at both 10 and 20 min post-injection of 1 μg AVT. These results indicate that AVT has prolactin-releasing activity and that this activity is not dependent upon the presence of an intact pineal gland.

Original languageEnglish (US)
Pages (from-to)1319-1322
Number of pages4
JournalEndocrinology
Volume99
Issue number5
DOIs
Publication statusPublished - Nov 1976

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ASJC Scopus subject areas

  • Endocrinology

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