Dopamine-CNS pathways and neurophysiology

A. A. Grace, D. J. Lodge, D. M. Buffalari

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


The dopamine (DA) systems of the brain are an important neuromodulator system that have drawn the attention of investigators due to their known role in a variety of neurological and psychiatric disorders. Unlike other monoamine neurotransmitters, these extensively collateralized systems exhibit discreet projections, enabling them to independently coordinate cognitive, affective, and motor aspects of behavior. The DA neurons themselves are subject to extensive and complex regulation. In this article, we review the principal electrophysiological characteristics of DA neurons, as well as the intrinsic and extrinsic regulation of their activity and firing patterns.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Number of pages7
ISBN (Print)9780080450469
StatePublished - Jan 1 2009
Externally publishedYes


  • Afferent pathways
  • Burst firing
  • Dopamine neuron
  • Electrophysiology
  • Mesocortical
  • Mesolimbic
  • Nigrostriatal
  • Substantia nigra
  • Tonic/phasic model
  • Ventral tegmental area

ASJC Scopus subject areas

  • Neuroscience(all)


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