Does maximal serotonin N-acetyltransferase activity necessarily reflect maximal melatonin production in the rat pineal gland?

T. S. King, S. Steinlechner, R. J. Reiter

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p-Chlorophenylalanine (PCPA) treatment reduced pineal 5-hydroxytryptamine (5-HT) levels by 68.9% of non-PCPA treated levels in intact rat pineal glands and by 95.9% of non-PCPA treated levels in adrenergically denervated rat pineal glands. Although isoproterenol stimulation resulted in increased activity of serotonin N-acetyltransferase (NAT) activity in all experimental groups, pineal melatonin production was maximal only in non-PCPA treated rats, suggesting that 5-HT concentrations may exert considerable influence on the level of melatonin production in the rat pineal gland, independent of the level of NAT activity.

Original languageEnglish (US)
Pages (from-to)343-347
Number of pages5
JournalNeuroscience Letters
Issue number3
StatePublished - Aug 10 1984



  • isoproterenol
  • melatonin
  • p-chlorophenylalanine
  • pineal gland
  • rat
  • serotonin N-acetyltransferase

ASJC Scopus subject areas

  • Neuroscience(all)

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