Abstract
p-Chlorophenylalanine (PCPA) treatment reduced pineal 5-hydroxytryptamine (5-HT) levels by 68.9% of non-PCPA treated levels in intact rat pineal glands and by 95.9% of non-PCPA treated levels in adrenergically denervated rat pineal glands. Although isoproterenol stimulation resulted in increased activity of serotonin N-acetyltransferase (NAT) activity in all experimental groups, pineal melatonin production was maximal only in non-PCPA treated rats, suggesting that 5-HT concentrations may exert considerable influence on the level of melatonin production in the rat pineal gland, independent of the level of NAT activity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 343-347 |
| Number of pages | 5 |
| Journal | Neuroscience Letters |
| Volume | 48 |
| Issue number | 3 |
| DOIs | |
| State | Published - Aug 10 1984 |
Keywords
- isoproterenol
- melatonin
- p-chlorophenylalanine
- pineal gland
- rat
- serotonin N-acetyltransferase
ASJC Scopus subject areas
- Neuroscience(all)