Does increasing the nodal yield improve outcomes in patients without nodal metastasis at radical cystectomy?

Michael Rink, Shahrokh F. Shariat, Evanguelos Xylinas, John P. Fitzgerald, Jens Hansen, David A. Green, Ashish M. Kamat, Giacomo Novara, Siamak Daneshmand, Yves Fradet, Scott T. Tagawa, Patrick J. Bastian, Wassim Kassouf, Quoc Dien Trinh, Pierre I. Karakiewicz, Hans Martin Fritsche, Derya Tilki, Felix K. Chun, Bjoern G. Volkmer, Marko BabjukAxel S. Merseburger, Douglas S. Scherr, Yair Lotan, Robert S. Svatek

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Purpose: To determine whether the number of lymph nodes (LNs) examined is associated with outcomes in patients without nodal metastasis after radical cystectomy (RC). Patients and Methods: We retrospectively analyzed data from 4,188 patients treated at 12 centers with RC and pelvic lymphadenectomy without neo-adjuvant chemotherapy for urothelial carcinoma of the bladder (UCB). Outcomes of patients without LN metastasis (n = 3,088) were examined according to the LN yield analyzed as continuous variable, tertiles, and using the cutoffs of ≥9 and ≥20. Results: The median nodal yield was 18 (range 1-123; IQR:20). A total of 2591 (84 %) and 1445 (47 %) patients had a LN yield ≥9 and ≥20, respectively. Median follow-up was 47 months (IQR:70). In multivariable analyses that adjusted for the standard clinicopathologic factors, higher LN yield was associated with a decreased risk of disease recurrence (continuous: HR = 0.996, p = 0.05; 3rd vs 1st tertile: HR = 0.853, p = 0.048; cutoff ≥20: HR = 0.851, p = 0.032). In the subgroups of patients with muscle-invasive UCB or those with ≥9 LN removed, LN yield was not associated with outcomes (p values >0.05). Conclusions: In this large multicenter cohort of patients with node-negative UCB, higher nodal yield improved recurrence-free survival when all patients were analyzed. Patients with a high LN yield (≥20 LN removed or 3rd tertile) had the largest benefit. The lack of prognostic significance of LN yield in patients with muscle-invasive UCB or those stratified by 9 LNs removed suggests that this effect is weak. Further prospective studies are needed to help identify preoperatively the optimal template for each patient.

Original languageEnglish (US)
Pages (from-to)807-814
Number of pages8
JournalWorld Journal of Urology
Volume30
Issue number6
DOIs
Publication statusPublished - Dec 1 2012

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Keywords

  • Bladder cancer
  • Lymph node
  • Radical cystectomy
  • Recurrence
  • Survival
  • Transitional cell carcinoma

ASJC Scopus subject areas

  • Urology

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