Does fasting interval affect the glucose challenge test?

Michael D. Berkus, Michael P. Stern, Braxton D. Michell, Edward R. Newton, Oded Langer

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The relationship between fasting interval and glucose screening was assessed in a prospective study of 153 non-diabetic pregnant patients undergoing a standard 50g glucose challenge test. An interval of less than 3 hours after the last meal was found to be associated with a significantly greater insulin response as opposed to a fasting interval of more than 3 hours (121.3 pmol/l vs. 83.5 pmol/l, p < .001) and a greater insulin/glucose index (0.92 vs. 0.66, p < .001), with no difference in plasma glucose. Overall, obese patients had a higher glucose response than non-obese, but only higher insulin levels (107 pmol/l vs. 69 pmol/l, p < .001) and insulin/glucose index (0.79 vs. 0.59, p < .02) when the fasting interval was greater than 3 hours. Our data suggest that the fasting interval can influence insulin response during a glucose challenge test and the aberration in insulin secretion may effect screening results, especially in the high-risk gravida with glucose abnormality.

Original languageEnglish (US)
Pages (from-to)1812-1817
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Issue number6 PART 1
StatePublished - Dec 1990


  • Gestational diabetes
  • fasting interval
  • glucose screening
  • insulin
  • obesity

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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