Does ethnicity moderate dementia's biomarkers?

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

We have used structural equation models to explicitly distinguish functional status, and therefore "dementia-relevant" variance in cognitive task performance (i.e., "δ") from that which is unrelated to a dementing process. Our approach results in a relatively "error-free" continuous variable that can serve as a dementia-specific phenotype. In this study, we associate δ with cytokines and other serum biomarkers in a well characterized Alzheimer's disease cohort, the Texas Alzheimer's Research and Care Consortium. Independent of covariates, δ is associated significantly with 12 serum biomarkers. These associations appear to be specific to non-Hispanic white participants.

Original languageEnglish (US)
Pages (from-to)336-344
Number of pages9
JournalNeurobiology of Aging
Volume35
Issue number2
DOIs
StatePublished - Feb 1 2014

Keywords

  • Aging
  • Cognition
  • Dementia
  • Functional status
  • G

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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