Does accounting for mitochondrial genetic variation improve the fit of genetic models?

S. A. Czerwinski, J. T. Williams, E. W. Demerath, B. Towne, R. M. Siervogel, J. Blangero

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We describe a simple variance component model for estimating the effect of mitochondrial DNA (mtDNA) inheritance on quantitative trait variation. The model is applied to quantitative trait Q5 in the simulated general population data from Genetic Analysis Workshop (GAW) 12. Although the mitochondrial effect on Q5 is small (5.3%) and the power of the method to detect the effect is correspondingly low, analysis over the available population replicates demonstrates that the effect of maternal relatedness can be detected and estimated accurately.

Original languageEnglish (US)
JournalGenetic Epidemiology
Volume21 Suppl 1
StatePublished - 2001
Externally publishedYes

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Mitochondrial Genes
Genetic Models
Population Genetics
Mitochondrial DNA
Mothers
Education
Population

ASJC Scopus subject areas

  • Genetics(clinical)
  • Epidemiology

Cite this

Czerwinski, S. A., Williams, J. T., Demerath, E. W., Towne, B., Siervogel, R. M., & Blangero, J. (2001). Does accounting for mitochondrial genetic variation improve the fit of genetic models? Genetic Epidemiology, 21 Suppl 1.

Does accounting for mitochondrial genetic variation improve the fit of genetic models? / Czerwinski, S. A.; Williams, J. T.; Demerath, E. W.; Towne, B.; Siervogel, R. M.; Blangero, J.

In: Genetic Epidemiology, Vol. 21 Suppl 1, 2001.

Research output: Contribution to journalArticle

Czerwinski, SA, Williams, JT, Demerath, EW, Towne, B, Siervogel, RM & Blangero, J 2001, 'Does accounting for mitochondrial genetic variation improve the fit of genetic models?', Genetic Epidemiology, vol. 21 Suppl 1.
Czerwinski SA, Williams JT, Demerath EW, Towne B, Siervogel RM, Blangero J. Does accounting for mitochondrial genetic variation improve the fit of genetic models? Genetic Epidemiology. 2001;21 Suppl 1.
Czerwinski, S. A. ; Williams, J. T. ; Demerath, E. W. ; Towne, B. ; Siervogel, R. M. ; Blangero, J. / Does accounting for mitochondrial genetic variation improve the fit of genetic models?. In: Genetic Epidemiology. 2001 ; Vol. 21 Suppl 1.
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