Does accounting for mitochondrial genetic variation improve the fit of genetic models?

S. A. Czerwinski, J. T. Williams, E. W. Demerath, B. Towne, R. M. Siervogel, J. Blangero

    Research output: Contribution to journalArticle

    6 Scopus citations

    Abstract

    We describe a simple variance component model for estimating the effect of mitochondrial DNA (mtDNA) inheritance on quantitative trait variation. The model is applied to quantitative trait Q5 in the simulated general population data from Genetic Analysis Workshop (GAW) 12. Although the mitochondrial effect on Q5 is small (5.3%) and the power of the method to detect the effect is correspondingly low, analysis over the available population replicates demonstrates that the effect of maternal relatedness can be detected and estimated accurately.

    Original languageEnglish (US)
    Pages (from-to)S779-782
    JournalGenetic epidemiology
    Volume21 Suppl 1
    StatePublished - 2001

      Fingerprint

    ASJC Scopus subject areas

    • Epidemiology
    • Genetics(clinical)

    Cite this

    Czerwinski, S. A., Williams, J. T., Demerath, E. W., Towne, B., Siervogel, R. M., & Blangero, J. (2001). Does accounting for mitochondrial genetic variation improve the fit of genetic models? Genetic epidemiology, 21 Suppl 1, S779-782.