Do statins lower the risk of dementia?

D. A. Drachman, H. Jick, S. S. Jick, S. Seshadri

Research output: Contribution to journalArticlepeer-review


We studied three groups of patients older than 50 years from the United Kingdom General Practice Research Database, totaling 60,000 patients from 368 practices. Patients were grouped as follows: normal cholesterol levels, elevated cholesterol treated with HMG-CoA reductase inhibitors (statins) or other lipid-lowering drugs, and untreated elevated cholesterol. Of these patients, 284 developed dementia and were matched with 1,080 controls. Patients taking statins had a 70% lower risk of dementia than patients without hyperlipidemia and those with hyperlipidemia who were untreated or treated with nonstatin drugs. Statins may prevent dementia; randomized clinical trials are needed to confirm this finding.

Original languageEnglish (US)
Pages (from-to)27-31
Number of pages5
JournalCardiology Review
Issue number12
StatePublished - Dec 13 2001
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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