Do statins lower the risk of dementia?

D. A. Drachman, H. Jick, S. S. Jick, S. Seshadri

Research output: Contribution to journalArticle


We studied three groups of patients older than 50 years from the United Kingdom General Practice Research Database, totaling 60,000 patients from 368 practices. Patients were grouped as follows: normal cholesterol levels, elevated cholesterol treated with HMG-CoA reductase inhibitors (statins) or other lipid-lowering drugs, and untreated elevated cholesterol. Of these patients, 284 developed dementia and were matched with 1,080 controls. Patients taking statins had a 70% lower risk of dementia than patients without hyperlipidemia and those with hyperlipidemia who were untreated or treated with nonstatin drugs. Statins may prevent dementia; randomized clinical trials are needed to confirm this finding.

Original languageEnglish (US)
Pages (from-to)27-31
Number of pages5
JournalCardiology Review
Issue number12
StatePublished - Dec 13 2001
Externally publishedYes


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Drachman, D. A., Jick, H., Jick, S. S., & Seshadri, S. (2001). Do statins lower the risk of dementia? Cardiology Review, 18(12), 27-31.