Abstract
Outcome for 105 patients with candidemia treated with amphotericin B was correlated with amphotericin B in vitro susceptibility results. Thirty-three patients had microbiologic failure, which was defined as persistence of Candida in the bloodstream despite ≤3 days of amphotericin B. Amphotericin B minimum inhibitory concentrations (MICs) were determined by the National Committee for Clinical Laboratory Standards methodology. After determination of MICs, the minimal lethal concentrations (MLCs) were determined. The isolates tested yielded a narrow range of amphotericin B MICs (0.06-2 μg/mL); only 5% (5/105) exhibited MICs ≤1 μg/mL. The MLC range, on the other hand, was significantly broader (0.125 to > 16 μg/mL); 24% (25/105) exhibited MLCs ≤1 μg/mL. The strongest predictor for microbiologic failure was 48-h MLC (P < .001), followed by 24-h MLC (P = .03) and 48-h MIC (P = .11). A resistant break point for amphotericin B of >1 μg/mL for MLC and ≤ 1 μg/mL for MIC could be inferred from this study.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 425-430 |
| Number of pages | 6 |
| Journal | Journal of Infectious Diseases |
| Volume | 177 |
| Issue number | 2 |
| State | Published - 1998 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Immunology
Cite this
Do in vitro susceptibility data predict the microbiologic response to amphotericin B? Results of a prospective study of patients with Candida fungemia. / Nguyen, M. Hong; Clancy, Cornelius J.; Yu, Victor L.; Yu, Yue C.; Morris, Arthur J.; Snydman, David R.; Sutton, Deanna A.; Rinaldi, Michael G.
In: Journal of Infectious Diseases, Vol. 177, No. 2, 1998, p. 425-430.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Do in vitro susceptibility data predict the microbiologic response to amphotericin B? Results of a prospective study of patients with Candida fungemia
AU - Nguyen, M. Hong
AU - Clancy, Cornelius J.
AU - Yu, Victor L.
AU - Yu, Yue C.
AU - Morris, Arthur J.
AU - Snydman, David R.
AU - Sutton, Deanna A.
AU - Rinaldi, Michael G.
PY - 1998
Y1 - 1998
N2 - Outcome for 105 patients with candidemia treated with amphotericin B was correlated with amphotericin B in vitro susceptibility results. Thirty-three patients had microbiologic failure, which was defined as persistence of Candida in the bloodstream despite ≤3 days of amphotericin B. Amphotericin B minimum inhibitory concentrations (MICs) were determined by the National Committee for Clinical Laboratory Standards methodology. After determination of MICs, the minimal lethal concentrations (MLCs) were determined. The isolates tested yielded a narrow range of amphotericin B MICs (0.06-2 μg/mL); only 5% (5/105) exhibited MICs ≤1 μg/mL. The MLC range, on the other hand, was significantly broader (0.125 to > 16 μg/mL); 24% (25/105) exhibited MLCs ≤1 μg/mL. The strongest predictor for microbiologic failure was 48-h MLC (P < .001), followed by 24-h MLC (P = .03) and 48-h MIC (P = .11). A resistant break point for amphotericin B of >1 μg/mL for MLC and ≤ 1 μg/mL for MIC could be inferred from this study.
AB - Outcome for 105 patients with candidemia treated with amphotericin B was correlated with amphotericin B in vitro susceptibility results. Thirty-three patients had microbiologic failure, which was defined as persistence of Candida in the bloodstream despite ≤3 days of amphotericin B. Amphotericin B minimum inhibitory concentrations (MICs) were determined by the National Committee for Clinical Laboratory Standards methodology. After determination of MICs, the minimal lethal concentrations (MLCs) were determined. The isolates tested yielded a narrow range of amphotericin B MICs (0.06-2 μg/mL); only 5% (5/105) exhibited MICs ≤1 μg/mL. The MLC range, on the other hand, was significantly broader (0.125 to > 16 μg/mL); 24% (25/105) exhibited MLCs ≤1 μg/mL. The strongest predictor for microbiologic failure was 48-h MLC (P < .001), followed by 24-h MLC (P = .03) and 48-h MIC (P = .11). A resistant break point for amphotericin B of >1 μg/mL for MLC and ≤ 1 μg/mL for MIC could be inferred from this study.
UR - http://www.scopus.com/inward/record.url?scp=0031883309&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031883309&partnerID=8YFLogxK
M3 - Article
C2 - 9466531
AN - SCOPUS:0031883309
VL - 177
SP - 425
EP - 430
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 2
ER -