DNA synthesis in the oocyte of the mature mouse: A radioautographic study

Terrell R. Hoage, Ivan L. Cameron

Research output: Contribution to journalArticlepeer-review

Abstract

Mice were injected three times over an 8‐hour period with a total of 48 m̈ci 3H‐T/gm of body weight and were sacrificed 1, 3, 5, 9 and 17 days afterwards. Radioautographs of the ovaries showed significantly higher grain counts in oocytes of follicles that are in the antrum formation stage. The radioautographic visualization of DNase digestible 3H‐thymidine incorporation into the juxtanucleolar region in oocytes of mature mice occurs in association with oocyte growth in follicles that are in the antrum formation stage. The scheduled disappearance of this juxtanucleolar oocyte DNA and its label during later oocyte growth suggests a degradation or dispersion of this labeled DNA prior to ovulation.

Original languageEnglish (US)
Pages (from-to)585-594
Number of pages10
JournalThe Anatomical Record
Volume186
Issue number4
DOIs
StatePublished - Dec 1976
Externally publishedYes

ASJC Scopus subject areas

  • Anatomy
  • Agricultural and Biological Sciences (miscellaneous)

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