DNA polymorphic loci mapped to human chromosomes 3, 5, 9, 11, 17, 18 and 22

S. L. Naylor, A. Y. Sakaguchi, D. Barker

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Using the techniques of Southern filter hybridization and somatic cell genetics, seven genomic DNA fragments recognizing DNA polymorphic loci were mapped to specific chromosomes and regions of chromosomes. The seven probes, isolated from human genomic libraries, lacked repetitive sequences and were hybridized to DNA isolated from a set of human-rodent somatic cell hybrids segregating human chromosomes. These probes detected DNA sequences on human chromosomes 3, 5, 9, 11, 17, 18, and 22. These DNA polymorphic sites, which occur in 10% or greater of the population, will serve as markers for linkage studies with known polymorphic loci as well as to establish linkage with disease loci.

Original languageEnglish (US)
Pages (from-to)2447-2451
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume81
Issue number8 I
DOIs
StatePublished - 1984

ASJC Scopus subject areas

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