DNA double-strand break processing: The beginning of the end

Steven Raynard, Hengyao Niu, Patrick Sung

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

Nucleolytic processing of DNA double-strand breaks (DSBs) generates 3′ ssDNA tails that are essential for the assembly of DNA damage checkpoint signaling and DNA repair protein complexes. Genetic studies have provided evidence that multiple nuclease activities are involved in DSB end resection. Three recent studies, including work by Jackson and colleagues (pp. 2767-2772) in the October 15, 2008, issue of Genes & Development, have begun to shed some light on the intricacy of this process.

Original languageEnglish (US)
Pages (from-to)2903-2907
Number of pages5
JournalGenes and Development
Volume22
Issue number21
DOIs
StatePublished - Nov 1 2008
Externally publishedYes

Keywords

  • ATR
  • DNA damage checkpoint
  • DNA repair
  • DNA resection
  • Exonuclease 1
  • RecQ helicases

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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