DNA double-strand break processing: The beginning of the end

Steven Raynard; Hengyao Niu; Patrick Sung

doi:10.1101/gad.1742408

DNA double-strand break processing: The beginning of the end

Steven Raynard, Hengyao Niu, Patrick Sung

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Abstract

Nucleolytic processing of DNA double-strand breaks (DSBs) generates 3′ ssDNA tails that are essential for the assembly of DNA damage checkpoint signaling and DNA repair protein complexes. Genetic studies have provided evidence that multiple nuclease activities are involved in DSB end resection. Three recent studies, including work by Jackson and colleagues (pp. 2767-2772) in the October 15, 2008, issue of Genes & Development, have begun to shed some light on the intricacy of this process.

Original language	English (US)
Pages (from-to)	2903-2907
Number of pages	5
Journal	Genes and Development
Volume	22
Issue number	21
DOIs	https://doi.org/10.1101/gad.1742408
State	Published - Nov 1 2008
Externally published	Yes

Keywords

ATR
DNA damage checkpoint
DNA repair
DNA resection
Exonuclease 1
RecQ helicases

ASJC Scopus subject areas

General Medicine

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10.1101/gad.1742408

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title = "DNA double-strand break processing: The beginning of the end",

abstract = "Nucleolytic processing of DNA double-strand breaks (DSBs) generates 3′ ssDNA tails that are essential for the assembly of DNA damage checkpoint signaling and DNA repair protein complexes. Genetic studies have provided evidence that multiple nuclease activities are involved in DSB end resection. Three recent studies, including work by Jackson and colleagues (pp. 2767-2772) in the October 15, 2008, issue of Genes & Development, have begun to shed some light on the intricacy of this process.",

keywords = "ATR, DNA damage checkpoint, DNA repair, DNA resection, Exonuclease 1, RecQ helicases",

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T2 - The beginning of the end

AU - Raynard, Steven

AU - Niu, Hengyao

AU - Sung, Patrick

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Y1 - 2008/11/1

N2 - Nucleolytic processing of DNA double-strand breaks (DSBs) generates 3′ ssDNA tails that are essential for the assembly of DNA damage checkpoint signaling and DNA repair protein complexes. Genetic studies have provided evidence that multiple nuclease activities are involved in DSB end resection. Three recent studies, including work by Jackson and colleagues (pp. 2767-2772) in the October 15, 2008, issue of Genes & Development, have begun to shed some light on the intricacy of this process.

AB - Nucleolytic processing of DNA double-strand breaks (DSBs) generates 3′ ssDNA tails that are essential for the assembly of DNA damage checkpoint signaling and DNA repair protein complexes. Genetic studies have provided evidence that multiple nuclease activities are involved in DSB end resection. Three recent studies, including work by Jackson and colleagues (pp. 2767-2772) in the October 15, 2008, issue of Genes & Development, have begun to shed some light on the intricacy of this process.

KW - ATR

KW - DNA damage checkpoint

KW - DNA repair

KW - DNA resection

KW - Exonuclease 1

KW - RecQ helicases

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JF - Genes and Development

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DNA double-strand break processing: The beginning of the end

Abstract

Keywords

ASJC Scopus subject areas

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