@article{a6211d23d7d5439a944e41ce43c55e13,
title = "DNA damage-induced cell cycle checkpoints involve both p53-dependent and -independent pathways: Role of telomere repeat binding factor 2",
abstract = "Treatment of colon cancer cells with MNNG causes DNA damage with reduced telomeric signals in a p53-dependent manner, but increased cell cycle arrest in S-G2/M by both p53-dependent and independent mechanisms. Results also indicate that cellular levels of TRF2 may play a critical role in MNNG-induced cell cycle arrest and apoptosis of colon cancer cells.",
keywords = "Apoptosis, Cell cycle arrest, DNA damage, TRF1, TRF2, Telomere, p53",
author = "S. Narayan and Jaiswal, {A. S.} and Multani, {A. S.} and S. Pathak",
note = "Funding Information: We are grateful to Dr Bert Vogelstein (The Johns Hopkins Oncology Center, The Johns Hopkins University, Baltimore, MD) for HCT-116(p53–/–) and HCT-116(p53+/+) cell lines, Dr Stratford May for critically reading the manuscript, Dr Virendra Kumar for technical assistance, and Nirupama Gupta for editorial comments. The FACS analysis was performed in the FCC Laboratory of the ICBR of the University of Florida. This work was supported by NIH grants CA77721 (to SN) and RRO4999 (to SP).",
year = "2001",
month = sep,
day = "14",
doi = "10.1054/bjoc.2001.2002",
language = "English (US)",
volume = "85",
pages = "898--901",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Springer Nature",
number = "6",
}