DNA damage-induced cell cycle checkpoints involve both p53-dependent and -independent pathways: Role of telomere repeat binding factor 2

S. Narayan, A. S. Jaiswal, A. S. Multani, S. Pathak

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Treatment of colon cancer cells with MNNG causes DNA damage with reduced telomeric signals in a p53-dependent manner, but increased cell cycle arrest in S-G2/M by both p53-dependent and independent mechanisms. Results also indicate that cellular levels of TRF2 may play a critical role in MNNG-induced cell cycle arrest and apoptosis of colon cancer cells.

Original languageEnglish (US)
Pages (from-to)898-901
Number of pages4
JournalBritish Journal of Cancer
Volume85
Issue number6
DOIs
StatePublished - Sep 14 2001
Externally publishedYes

Keywords

  • Apoptosis
  • Cell cycle arrest
  • DNA damage
  • TRF1
  • TRF2
  • Telomere
  • p53

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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