DNA Damage and Repair in Eye Diseases

Joanna Sohn, Sang Eun Lee, Eun Yong Shim

Research output: Contribution to journalReview articlepeer-review


Vision is vital for daily activities, and yet the most common eye diseases—cataracts, DR, ARMD, and glaucoma—lead to blindness in aging eyes. Cataract surgery is one of the most frequently performed surgeries, and the outcome is typically excellent if there is no concomitant pathology present in the visual pathway. In contrast, patients with DR, ARMD and glaucoma often develop significant visual impairment. These often-multifactorial eye problems can have genetic and hereditary components, with recent data supporting the role of DNA damage and repair as significant pathogenic factors. In this article, we discuss the role of DNA damage and the repair deficit in the development of DR, ARMD and glaucoma.

Original languageEnglish (US)
Article number3916
JournalInternational journal of molecular sciences
Issue number4
StatePublished - Feb 2023


  • age-related macular degeneration
  • diabetic retinopathy
  • DNA damage and repair
  • glaucoma

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


Dive into the research topics of 'DNA Damage and Repair in Eye Diseases'. Together they form a unique fingerprint.

Cite this