Diversity of Bipolaris species in clinical samples in the United States and their antifungal susceptibility profiles

K. C. Da Cunha, D. A. Sutton, A. W. Fothergill, J. Cano, J. Gené, H. Madrid, S. De Hoog, P. W. Crous, J. Guarro

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42 Scopus citations

Abstract

A set of 104 isolates from human clinical samples from the United States, morphologically compatible with Bipolaris, were morphologically and molecularly identified through the sequence analysis of the internal transcribed space (ITS) region of the nuclear ribosomal DNA (rDNA). The predominant species was Bipolaris spicifera (67.3%), followed by B. hawaiiensis (18.2%), B. cynodontis (8.6%), B. micropus (2.9%), B. australiensis (2%), and B. setariae (1%). Bipolaris cynodontis, B. micropus, and B. setariae represent new records from clinical samples. The most common anatomical sites where isolates were recovered were the nasal region (30.7%), skin (19.2%), lungs (14.4%), and eyes (12.5%). The antifungal susceptibilities of 5 species of Bipolaris to 9 drugs are provided. With the exception of fluconazole and flucytosine, the antifungals tested showed good activity.

Original languageEnglish (US)
Pages (from-to)4061-4066
Number of pages6
JournalJournal of clinical microbiology
Volume50
Issue number12
DOIs
StatePublished - Dec 2012

ASJC Scopus subject areas

  • Microbiology (medical)

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    Da Cunha, K. C., Sutton, D. A., Fothergill, A. W., Cano, J., Gené, J., Madrid, H., De Hoog, S., Crous, P. W., & Guarro, J. (2012). Diversity of Bipolaris species in clinical samples in the United States and their antifungal susceptibility profiles. Journal of clinical microbiology, 50(12), 4061-4066. https://doi.org/10.1128/JCM.01965-12