Diverse biological activities of the vascular non-inflammatory molecules - The Vanin pantetheinases

Belinda J. Kaskow, J. Michael Proffit, John Blangero, Eric K. Moses, Lawrence J. Abraham

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The Vanin genes are a family that encode pantetheinases involved in recycling Coenzyme A, catalysing the breakdown of intermediate pantetheine to vitamin B5 for reuse in CoA biosynthesis. The role of pantetheinase in this most fundamental of cellular processes, was substantially characterised by the 1970s. The next 20. years saw little further interest in pantetheinase until various genetic studies implicated the Vanin locus in a range of normal and disease phenotypes, and a consequent interest in the other product of pantetheinase activity, cysteamine. This report seeks to bring together the early biochemical studies with recent biological data implicating cysteamine as a regulator of the oxidative state of a cell. Numerous studies now report a role for Vanin in inflammation, oxidative stress, cell migration and numerous diseases including cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)653-658
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume417
Issue number2
DOIs
StatePublished - Jan 13 2012
Externally publishedYes

Fingerprint

Bioactivity
Blood Vessels
Cysteamine
Molecules
Coenzyme A
Pantetheine
Pantothenic Acid
Oxidative stress
Biosynthesis
Recycling
Cell Movement
Reference Values
Oxidative Stress
Cardiovascular Diseases
Genes
Inflammation
Phenotype
pantetheinase

Keywords

  • Cardiovascular disease
  • Cysteamine
  • Pantetheinase
  • Vanin

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

Diverse biological activities of the vascular non-inflammatory molecules - The Vanin pantetheinases. / Kaskow, Belinda J.; Michael Proffit, J.; Blangero, John; Moses, Eric K.; Abraham, Lawrence J.

In: Biochemical and Biophysical Research Communications, Vol. 417, No. 2, 13.01.2012, p. 653-658.

Research output: Contribution to journalArticle

Kaskow, Belinda J. ; Michael Proffit, J. ; Blangero, John ; Moses, Eric K. ; Abraham, Lawrence J. / Diverse biological activities of the vascular non-inflammatory molecules - The Vanin pantetheinases. In: Biochemical and Biophysical Research Communications. 2012 ; Vol. 417, No. 2. pp. 653-658.
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