Diverse biological activities of the vascular non-inflammatory molecules - The Vanin pantetheinases

Belinda J. Kaskow, J. Michael Proffit, John Blangero, Eric K. Moses, Lawrence J. Abraham

    Research output: Contribution to journalShort surveypeer-review

    45 Scopus citations

    Abstract

    The Vanin genes are a family that encode pantetheinases involved in recycling Coenzyme A, catalysing the breakdown of intermediate pantetheine to vitamin B5 for reuse in CoA biosynthesis. The role of pantetheinase in this most fundamental of cellular processes, was substantially characterised by the 1970s. The next 20. years saw little further interest in pantetheinase until various genetic studies implicated the Vanin locus in a range of normal and disease phenotypes, and a consequent interest in the other product of pantetheinase activity, cysteamine. This report seeks to bring together the early biochemical studies with recent biological data implicating cysteamine as a regulator of the oxidative state of a cell. Numerous studies now report a role for Vanin in inflammation, oxidative stress, cell migration and numerous diseases including cardiovascular disease.

    Original languageEnglish (US)
    Pages (from-to)653-658
    Number of pages6
    JournalBiochemical and Biophysical Research Communications
    Volume417
    Issue number2
    DOIs
    StatePublished - Jan 13 2012

    Keywords

    • Cardiovascular disease
    • Cysteamine
    • Pantetheinase
    • Vanin

    ASJC Scopus subject areas

    • Biophysics
    • Biochemistry
    • Molecular Biology
    • Cell Biology

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