Diverse actions of the modulatory peptide neurotensin on central synaptic transmission

Christopher W. Tschumi, Michael J. Beckstead

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Neurotensin (NT) is a 13 amino acid neuropeptide that is expressed throughout the central nervous system and is implicated in the etiology of multiple diseases and disorders. Many primary investigations of NT-induced modulation of neuronal excitability at the level of the synapse have been conducted, but they have not been summarized in review form in nearly 30 years. Therefore, the goal of this review is to discuss the many actions of NT on neuronal excitability across brain regions as well as NT circuit architecture. In the basal ganglia as well as other brain nuclei, NT can act through diverse intracellular signaling cascades to enhance or depress neuronal activity by modulating activity of ion channels, ionotropic and metabotropic neurotransmitter receptors, and presynaptic release of neurotransmitters. Further, NT can produce indirect effects by evoking endocannabinoid release, and recently has itself been identified as a putative retrograde messenger. In the basal ganglia, the diverse actions and circuit architecture of NT signaling allow for input-specific control of reward-related behaviors.

Original languageEnglish (US)
Pages (from-to)784-793
Number of pages10
JournalEuropean Journal of Neuroscience
Issue number6
StatePublished - Mar 2019


  • VTA
  • endocannabinoids
  • methamphetamine
  • neuropeptide
  • substantia nigra

ASJC Scopus subject areas

  • Neuroscience(all)


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