Abstract
Venlafaxine (VEN) and its metabolite O-desmethylvenlafaxine (ODV) inhibit reuptake of serotonin and norepinephrine. This study examines whether VEN is differentially distributed in postmortem brain and examines relationships between brain and femoral blood concentrations from donors prescribed VEN for treatment of depression. Using high-pressure liquid chromatography-ultraviolet detection, VEN and ODV concentrations were measured in temporal, occipital, and cerebellar cortex of six postmortem brains. The ODV/VEN ratio was calculated as a relative measure of drug metabolism within each region where higher ratios indicated a greater conversion of VEN to ODV. Compared to the other regions examined, the cerebellum showed decreased VEN (p = 0.056), ODV (p = 0.006), and ODV/VEN (p = 0.027) ratios. In parts per million, VEN was higher in temporal and occipital cortex, but not cerebellum, as compared to femoral blood concentration. These observations suggest that VEN and ODV are differentially distributed in the brain, and metabolism of VEN to ODV may vary across brain regions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 683-689 |
| Number of pages | 7 |
| Journal | Journal of Forensic Sciences |
| Volume | 59 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2014 |
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Keywords
- Antidepressants
- Brain tissue
- Forensic science
- High-pressure liquid chromatography-ultraviolet detection
- Toxicology
- Venlafaxine
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Genetics
Cite this
Distribution of venlafaxine, O-desmethylvenlafaxine, and O-desmethylvenlafaxine to venlafaxine ratio in postmortem human brain tissue. / Murrell, Meredith D.; Cruz, Dianne A.; Javors, Martin A; Thompson, Peter M.
In: Journal of Forensic Sciences, Vol. 59, No. 3, 2014, p. 683-689.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Distribution of venlafaxine, O-desmethylvenlafaxine, and O-desmethylvenlafaxine to venlafaxine ratio in postmortem human brain tissue
AU - Murrell, Meredith D.
AU - Cruz, Dianne A.
AU - Javors, Martin A
AU - Thompson, Peter M.
PY - 2014
Y1 - 2014
N2 - Venlafaxine (VEN) and its metabolite O-desmethylvenlafaxine (ODV) inhibit reuptake of serotonin and norepinephrine. This study examines whether VEN is differentially distributed in postmortem brain and examines relationships between brain and femoral blood concentrations from donors prescribed VEN for treatment of depression. Using high-pressure liquid chromatography-ultraviolet detection, VEN and ODV concentrations were measured in temporal, occipital, and cerebellar cortex of six postmortem brains. The ODV/VEN ratio was calculated as a relative measure of drug metabolism within each region where higher ratios indicated a greater conversion of VEN to ODV. Compared to the other regions examined, the cerebellum showed decreased VEN (p = 0.056), ODV (p = 0.006), and ODV/VEN (p = 0.027) ratios. In parts per million, VEN was higher in temporal and occipital cortex, but not cerebellum, as compared to femoral blood concentration. These observations suggest that VEN and ODV are differentially distributed in the brain, and metabolism of VEN to ODV may vary across brain regions.
AB - Venlafaxine (VEN) and its metabolite O-desmethylvenlafaxine (ODV) inhibit reuptake of serotonin and norepinephrine. This study examines whether VEN is differentially distributed in postmortem brain and examines relationships between brain and femoral blood concentrations from donors prescribed VEN for treatment of depression. Using high-pressure liquid chromatography-ultraviolet detection, VEN and ODV concentrations were measured in temporal, occipital, and cerebellar cortex of six postmortem brains. The ODV/VEN ratio was calculated as a relative measure of drug metabolism within each region where higher ratios indicated a greater conversion of VEN to ODV. Compared to the other regions examined, the cerebellum showed decreased VEN (p = 0.056), ODV (p = 0.006), and ODV/VEN (p = 0.027) ratios. In parts per million, VEN was higher in temporal and occipital cortex, but not cerebellum, as compared to femoral blood concentration. These observations suggest that VEN and ODV are differentially distributed in the brain, and metabolism of VEN to ODV may vary across brain regions.
KW - Antidepressants
KW - Brain tissue
KW - Forensic science
KW - High-pressure liquid chromatography-ultraviolet detection
KW - Toxicology
KW - Venlafaxine
UR - http://www.scopus.com/inward/record.url?scp=84899125631&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84899125631&partnerID=8YFLogxK
U2 - 10.1111/1556-4029.12393
DO - 10.1111/1556-4029.12393
M3 - Article
C2 - 24502274
AN - SCOPUS:84899125631
VL - 59
SP - 683
EP - 689
JO - Journal of Forensic Sciences
JF - Journal of Forensic Sciences
SN - 0022-1198
IS - 3
ER -