Distribution of the lithium ion in endocrine organs of the rat

S. Stern, A. Frazer, J. Mendels, C. Frustaci

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Lithium ions accumulated consistently in the pituitary and thyroid of rats at concentrations significantly greater than in plasma. There was also a significant, although lower, accumulation of Li+ in the adrenal gland. No accumulation of lithium ion was noted in the testis or in the ovary. The possible significance of these findings with regard to some of the side effects of lithium carbonate treatment is discussed.

Original languageEnglish (US)
Pages (from-to)1669-1674
Number of pages6
JournalLife Sciences
Issue number10
StatePublished - May 15 1977

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology


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