Distribution of the lithium ion in endocrine organs of the rat

S. Stern; A. Frazer; J. Mendels; C. Frustaci

doi:10.1016/0024-3205(77)90341-1

Distribution of the lithium ion in endocrine organs of the rat

S. Stern, A. Frazer, J. Mendels, C. Frustaci

Department of Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Lithium ions accumulated consistently in the pituitary and thyroid of rats at concentrations significantly greater than in plasma. There was also a significant, although lower, accumulation of Li⁺ in the adrenal gland. No accumulation of lithium ion was noted in the testis or in the ovary. The possible significance of these findings with regard to some of the side effects of lithium carbonate treatment is discussed.

Original language	English (US)
Pages (from-to)	1669-1674
Number of pages	6
Journal	Life Sciences
Volume	20
Issue number	10
DOIs	https://doi.org/10.1016/0024-3205(77)90341-1
State	Published - May 15 1977

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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title = "Distribution of the lithium ion in endocrine organs of the rat",

abstract = "Lithium ions accumulated consistently in the pituitary and thyroid of rats at concentrations significantly greater than in plasma. There was also a significant, although lower, accumulation of Li+ in the adrenal gland. No accumulation of lithium ion was noted in the testis or in the ovary. The possible significance of these findings with regard to some of the side effects of lithium carbonate treatment is discussed.",

author = "S. Stern and A. Frazer and J. Mendels and C. Frustaci",

note = "Funding Information: 'Supported by funds from Veterans Administration and USPHS Grant from NIMH (PRB) # MH 25433 .",

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AU - Stern, S.

AU - Frazer, A.

AU - Mendels, J.

AU - Frustaci, C.

N1 - Funding Information: 'Supported by funds from Veterans Administration and USPHS Grant from NIMH (PRB) # MH 25433 .

PY - 1977/5/15

Y1 - 1977/5/15

N2 - Lithium ions accumulated consistently in the pituitary and thyroid of rats at concentrations significantly greater than in plasma. There was also a significant, although lower, accumulation of Li+ in the adrenal gland. No accumulation of lithium ion was noted in the testis or in the ovary. The possible significance of these findings with regard to some of the side effects of lithium carbonate treatment is discussed.

AB - Lithium ions accumulated consistently in the pituitary and thyroid of rats at concentrations significantly greater than in plasma. There was also a significant, although lower, accumulation of Li+ in the adrenal gland. No accumulation of lithium ion was noted in the testis or in the ovary. The possible significance of these findings with regard to some of the side effects of lithium carbonate treatment is discussed.

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Distribution of the lithium ion in endocrine organs of the rat

Abstract

ASJC Scopus subject areas

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