Distribution of microtubules in prolactin cells of lactating rats

Jerzy B. Warchol, Damon C. Herbert, M. Glenn Williams, Edward G. Rennels

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The intracellular distribution of microtubules was studied using serial sections of prolactin cells in anterior pituitary glands from lactating rats. Numerous microtubules were present in these cells following fixation with glutaraldehyde and osmium tetroxide. The greatest number of microtubules were present in the Golgi complex, situated around the perimeter and in association with the cisternae, vesicles and developing secretory granules. Microtubules were found in channels between groups of parallel cisternae of rough surfaced endoplasmic reticulum and in close proximity to small vesicles. They were also located adjacent to mitochondria, the plasmalemma, the nuclear envelope, and among mature secretory granules. Due to their orientation within the cell, it is suggested that the microtubules may act to direct the movement of organelles from one region of the cell to another and to give internal support to the cell.

Original languageEnglish (US)
Pages (from-to)205-212
Number of pages8
JournalCell and Tissue Research
Volume159
Issue number2
DOIs
StatePublished - Jun 1975
Externally publishedYes

Keywords

  • Anterior pituitary gland
  • Electron microscopy
  • Microtubules
  • Prolactin cells

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

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