Distribution of lod scores in oligogenic linkage analysis.

J. T. Williams, K. E. North, L. J. Martin, A. G. Comuzzie, H. H. Göring, J. Blangero

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

In variance component oligogenic linkage analysis it can happen that the residual additive genetic variance bounds to zero when estimating the effect of the ith quantitative trait locus. Using quantitative trait Q1 from the Genetic Analysis Workshop 12 simulated general population data, we compare the observed lod scores from oligogenic linkage analysis with the empirical lod score distribution under a null model of no linkage. We find that zero residual additive genetic variance in the null model alters the usual distribution of the likelihood-ratio statistic.

Original languageEnglish (US)
Pages (from-to)S805-810
JournalGenetic epidemiology
Volume21 Suppl 1
DOIs
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

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