Distribution of lod scores in oligogenic linkage analysis.

J. T. Williams, K. E. North, L. J. Martin, A. G. Comuzzie, H. H. Göring, J. Blangero

    Research output: Contribution to journalArticle

    4 Scopus citations


    In variance component oligogenic linkage analysis it can happen that the residual additive genetic variance bounds to zero when estimating the effect of the ith quantitative trait locus. Using quantitative trait Q1 from the Genetic Analysis Workshop 12 simulated general population data, we compare the observed lod scores from oligogenic linkage analysis with the empirical lod score distribution under a null model of no linkage. We find that zero residual additive genetic variance in the null model alters the usual distribution of the likelihood-ratio statistic.

    Original languageEnglish (US)
    Pages (from-to)S805-810
    JournalGenetic epidemiology
    Volume21 Suppl 1
    StatePublished - 2001

    ASJC Scopus subject areas

    • Epidemiology
    • Genetics(clinical)

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    Williams, J. T., North, K. E., Martin, L. J., Comuzzie, A. G., Göring, H. H., & Blangero, J. (2001). Distribution of lod scores in oligogenic linkage analysis. Genetic epidemiology, 21 Suppl 1, S805-810. https://doi.org/10.1002/gepi.2001.21.s1.s805