Distribution of HLA genotypes in families of patients with acute leukemia: Implications for transplantation

Ka Wah Chan, Marilyn S. Pollack, David Braun, Richard J. O’Reilly, Bo Dupont

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The HLA genotypes of members of 104 families of patients with acute myelogeneous leukemia (AML), 89 families of patients with acute lymphocytic leukemia (ALL), and 40 control families were analyzed. The results indicate that the HLA genotype of both ALL and AML leukemic patients is found more frequently than the expected 25% among their siblings; the increase for AML patients is statistically significant. This suggests that an HLA-linked factor(s) conferring susceptibility to leukemia may also be associated with increased gametic survival. The chance of finding an HLA-matched sibling for bone marrow transplantation is increased.

Original languageEnglish (US)
Pages (from-to)613-615
Number of pages3
JournalTransplantation
Volume33
Issue number6
DOIs
StatePublished - Jun 1982
Externally publishedYes

ASJC Scopus subject areas

  • Transplantation

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