Distribution of HLA Antigens in Patients with Ewing's Sarcoma

Ka Wah Chan; Gerald Rosen; Marilyn S. Pollack

doi:10.1111/j.1399-0039.1980.tb00312.x

Distribution of HLA Antigens in Patients with Ewing's Sarcoma

Ka Wah Chan, Gerald Rosen, Marilyn S. Pollack

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Thirty‐eight unrelated Caucasian patients with Ewing's sarcoma were typed for HLA–A and B locus antigens. Although no significant differences in the distribution of these antigens were found in comparison with local controls, a trend towards increases in HLA–B8 and Aw19 complex antigens was noted. Although American blacks are only rarely affected by this tumor, the two black patients we typed both had the HLA–Aw19 complex antigen, Aw31. This suggests that a disease susceptibility factor may be in linkage disequilibrium with HLA–Aw19 complex HLA antigens.

Original language	English (US)
Pages (from-to)	314-316
Number of pages	3
Journal	Tissue Antigens
Volume	16
Issue number	4
DOIs	https://doi.org/10.1111/j.1399-0039.1980.tb00312.x
State	Published - Oct 1980
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Biochemistry
Genetics

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10.1111/j.1399-0039.1980.tb00312.x

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abstract = "Thirty‐eight unrelated Caucasian patients with Ewing's sarcoma were typed for HLA–A and B locus antigens. Although no significant differences in the distribution of these antigens were found in comparison with local controls, a trend towards increases in HLA–B8 and Aw19 complex antigens was noted. Although American blacks are only rarely affected by this tumor, the two black patients we typed both had the HLA–Aw19 complex antigen, Aw31. This suggests that a disease susceptibility factor may be in linkage disequilibrium with HLA–Aw19 complex HLA antigens.",

author = "Chan, {Ka Wah} and Gerald Rosen and Pollack, {Marilyn S.}",

year = "1980",

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AU - Rosen, Gerald

AU - Pollack, Marilyn S.

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N2 - Thirty‐eight unrelated Caucasian patients with Ewing's sarcoma were typed for HLA–A and B locus antigens. Although no significant differences in the distribution of these antigens were found in comparison with local controls, a trend towards increases in HLA–B8 and Aw19 complex antigens was noted. Although American blacks are only rarely affected by this tumor, the two black patients we typed both had the HLA–Aw19 complex antigen, Aw31. This suggests that a disease susceptibility factor may be in linkage disequilibrium with HLA–Aw19 complex HLA antigens.

AB - Thirty‐eight unrelated Caucasian patients with Ewing's sarcoma were typed for HLA–A and B locus antigens. Although no significant differences in the distribution of these antigens were found in comparison with local controls, a trend towards increases in HLA–B8 and Aw19 complex antigens was noted. Although American blacks are only rarely affected by this tumor, the two black patients we typed both had the HLA–Aw19 complex antigen, Aw31. This suggests that a disease susceptibility factor may be in linkage disequilibrium with HLA–Aw19 complex HLA antigens.

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Distribution of HLA Antigens in Patients with Ewing's Sarcoma

Abstract

ASJC Scopus subject areas

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