Distribution of cerebral microbleeds in the East and West: Individual participant meta-analysis

Yusuke Yakushiji, Duncan Wilson, Gareth Ambler, Andreas Charidimou, Alexa Beiser, Mark A. Van Buchem, Charles Decarli, Ding Ding, Villi Gudnason, Hideo Hara, Toshio Imaizumi, Katsuhiko Kohara, Hyung Min Kwon, Lenore J. Launer, Vincent Mok, Thanh Phan, Sarah R. Preis, José Rafael Romero, Sudha Seshadri, Velandai SrikanthYuki Takashima, Yoshito Tsushima, Zhaolu Wang, Philip A. Wolf, Yunyun Xiong, Shuhei Yamaguchi, David J. Werring

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


We investigated differences in the anatomical distribution of cerebral microbleeds (CMBs) on MRI, hypothesized to indicate the type of underlying cerebral small vessel disease (SVD), between Eastern and Western general populations.MethodsWe analyzed data from 11 studies identified by a PubMed search between 1996 and April 2014 according to the Preferred Reporting Items for a Systematic Review and Meta-analysis of Individual Participant Data. Study quality measures indicated low or medium risk of bias. We included stroke-free participants from populations aged between 55 and 75 years, categorized by geographic location (Eastern or Western). We categorized CMB distribution (strictly lobar, deep and/or infratentorial [D/I], or mixed [i.e., CMBs located in both lobar and D/I regions]). We tested the hypothesis that Eastern and Western populations have different anatomical distributions of CMBs using multivariable mixed effects logistic regression analyses adjusted for age, sex, and hypertension and clustering by institution.ResultsAmong 8,595 stroke-free individuals (mean age [SD] 66.7 [5.6] years; 48% male; 42% from a Western population), 624 (7.3%) had CMBs (strictly lobar in 3.1%; D/I or mixed in 4.2%). In multivariable mixed effects models, Eastern populations had higher odds of D/I or mixed CMBs (adjusted odds ratio 2.78, 95% confidence interval [CI] 1.77-4.35) compared to Western populations. Eastern populations had a higher number of D/I or mixed CMBs (adjusted prevalence ratio 2.83, 95% CI 1.27-6.31).ConclusionsEastern and Western general populations have different anatomical distributions of CMBs, suggesting differences in the spectrum of predominant underlying SVDs, with potential implications for SVD diagnosis and treatment.

Original languageEnglish (US)
Pages (from-to)E1086-E1097
Issue number10
StatePublished - Mar 5 2019
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology


Dive into the research topics of 'Distribution of cerebral microbleeds in the East and West: Individual participant meta-analysis'. Together they form a unique fingerprint.

Cite this