Distraction of the frontal bone outside the cranial plane: A rabbit model

Constance M. Barone, Michael Ferder, David F. Jimenez, Leonard Grossman, Craig Flail, Berish Strauch, Ravelo V. Argamaso

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Distraction of the frontal bone outside the cranial plane using the Ilizarov principle was performed in 17 22-week-old New Zealand white rabbits. Five rabbits had frontal bone osteotomy only and were in the control group; 5 rabbits were placed in the sham control group and had frontal bone osteotomy plus application of a customized headgear appliance; and 7 rabbits were placed in the experimental group, which underwent frontal bone osteotomy application of the headgear and distraction. The frontal bone was elevated 1 mm every other day for a period of 8 weeks, and the animals were then killed. Cephalometry was performed both preoperatively and at the end of the 8- week period. Histological examination of the skulls was also performed. The experimental group showed a significantly elevated frontal bone compared to the sham control group (p < 0.05). Callous bone filled the distracted segment, which united the frontal bone with the cranial plane. Therefore, frontal bone advancement by distraction osteogenesis is possible using this rabbit model.

Original languageEnglish (US)
Pages (from-to)177-181
Number of pages5
JournalJournal of Craniofacial Surgery
Issue number3
StatePublished - Jul 1993


  • Craniosynostosis
  • Distraction
  • Frontal bone
  • Ilizarov principle

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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