Distinct subcortical tau burden: The tau pallido-claustral ratio separates progressive supranuclear palsy and corticobasal degeneration

Chelsey Sheng Qi Zhao; Lei Yan; Wenqing He; Lee Cyn Ang; Qi Zhang

doi:10.1111/bpa.13030

Distinct subcortical tau burden: The tau pallido-claustral ratio separates progressive supranuclear palsy and corticobasal degeneration

Chelsey Sheng Qi Zhao, Lei Yan, Wenqing He, Lee Cyn Ang, Qi Zhang

Research output: Contribution to journal › Letter › peer-review

Abstract

Neuropathological diagnosis of progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) requires interpretation of tau morphology based on extensive brain sampling. Here we report subcortical tau burden is sufficient to distinguish PSP and CBD, regardless of the tau morphology. The tau pallido-claustral ratio is a promising diagnostic indicator for PSP and CBD.

Original language	English (US)
Article number	e13030
Journal	Brain Pathology
Volume	32
Issue number	2
DOIs	https://doi.org/10.1111/bpa.13030
State	Published - Mar 2022
Externally published	Yes

Keywords

claustrum
corticobasal degeneration
digital pathology
progressive supranuclear palsy
tauopathy

ASJC Scopus subject areas

General Neuroscience
Pathology and Forensic Medicine
Clinical Neurology

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10.1111/bpa.13030

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title = "Distinct subcortical tau burden: The tau pallido-claustral ratio separates progressive supranuclear palsy and corticobasal degeneration",

abstract = "Neuropathological diagnosis of progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) requires interpretation of tau morphology based on extensive brain sampling. Here we report subcortical tau burden is sufficient to distinguish PSP and CBD, regardless of the tau morphology. The tau pallido-claustral ratio is a promising diagnostic indicator for PSP and CBD.",

keywords = "claustrum, corticobasal degeneration, digital pathology, progressive supranuclear palsy, tauopathy",

author = "Zhao, {Chelsey Sheng Qi} and Lei Yan and Wenqing He and Ang, {Lee Cyn} and Qi Zhang",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology.",

year = "2022",

month = mar,

doi = "10.1111/bpa.13030",

language = "English (US)",

volume = "32",

journal = "Brain Pathology",

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T1 - Distinct subcortical tau burden

T2 - The tau pallido-claustral ratio separates progressive supranuclear palsy and corticobasal degeneration

AU - Zhao, Chelsey Sheng Qi

AU - Yan, Lei

AU - He, Wenqing

AU - Ang, Lee Cyn

AU - Zhang, Qi

PY - 2022/3

Y1 - 2022/3

N2 - Neuropathological diagnosis of progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) requires interpretation of tau morphology based on extensive brain sampling. Here we report subcortical tau burden is sufficient to distinguish PSP and CBD, regardless of the tau morphology. The tau pallido-claustral ratio is a promising diagnostic indicator for PSP and CBD.

AB - Neuropathological diagnosis of progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) requires interpretation of tau morphology based on extensive brain sampling. Here we report subcortical tau burden is sufficient to distinguish PSP and CBD, regardless of the tau morphology. The tau pallido-claustral ratio is a promising diagnostic indicator for PSP and CBD.

KW - claustrum

KW - corticobasal degeneration

KW - digital pathology

KW - progressive supranuclear palsy

KW - tauopathy

UR - http://www.scopus.com/inward/record.url?scp=85117270670&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85117270670&partnerID=8YFLogxK

U2 - 10.1111/bpa.13030

DO - 10.1111/bpa.13030

M3 - Letter

C2 - 34672063

AN - SCOPUS:85117270670

SN - 1015-6305

VL - 32

JO - Brain Pathology

JF - Brain Pathology

IS - 2

M1 - e13030

ER -

Distinct subcortical tau burden: The tau pallido-claustral ratio separates progressive supranuclear palsy and corticobasal degeneration

Abstract

Keywords

ASJC Scopus subject areas

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