Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal

Vivienne I. Rebel; Andrew L. Kung; Elizabeth A. Tanner; Hong Yang; Roderick T. Bronson; David M. Livingston

doi:10.1073/pnas.232568499

Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal

Vivienne I. Rebel, Andrew L. Kung, Elizabeth A. Tanner, Hong Yang, Roderick T. Bronson, David M. Livingston

Greehey Children's Cancer Research Institute

Research output: Contribution to journal › Article

160 Scopus citations

Abstract

Hematopoietic stem cells (HSC) are tightly regulated through, as yet, undefined mechanisms that balance self-renewal and differentiation. We have identified a role for the transcriptional coactivators CREB-binding protein (CBP) and p300 in such HSC fate decisions. A full dose of CBP, but not p300, is crucial for HSC self-renewal. Conversely, p300, but not CBP, is essential for proper hematopoietic differentiation. Furthermore, in chimeric mice, hematologic malignancies emerged from both CBP^-/- and p300^-/- cell populations. Thus, CBP and p300 play essential but distinct roles in maintaining normal hematopoiesis, and, in mice, both are required for preventing hematologic tumorigenesis.

Original language	English (US)
Pages (from-to)	14789-14794
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	99
Issue number	23
DOIs	https://doi.org/10.1073/pnas.232568499
State	Published - Nov 12 2002

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Rebel, V. I., Kung, A. L., Tanner, E. A., Yang, H., Bronson, R. T., & Livingston, D. M. (2002). Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal. Proceedings of the National Academy of Sciences of the United States of America, 99(23), 14789-14794. https://doi.org/10.1073/pnas.232568499

Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal. / Rebel, Vivienne I.; Kung, Andrew L.; Tanner, Elizabeth A.; Yang, Hong; Bronson, Roderick T.; Livingston, David M.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, No. 23, 12.11.2002, p. 14789-14794.

Research output: Contribution to journal › Article

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10.1073/pnas.232568499