Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal

Vivienne I. Rebel, Andrew L. Kung, Elizabeth A. Tanner, Hong Yang, Roderick T. Bronson, David M. Livingston

Research output: Contribution to journalArticlepeer-review

165 Scopus citations

Abstract

Hematopoietic stem cells (HSC) are tightly regulated through, as yet, undefined mechanisms that balance self-renewal and differentiation. We have identified a role for the transcriptional coactivators CREB-binding protein (CBP) and p300 in such HSC fate decisions. A full dose of CBP, but not p300, is crucial for HSC self-renewal. Conversely, p300, but not CBP, is essential for proper hematopoietic differentiation. Furthermore, in chimeric mice, hematologic malignancies emerged from both CBP-/- and p300-/- cell populations. Thus, CBP and p300 play essential but distinct roles in maintaining normal hematopoiesis, and, in mice, both are required for preventing hematologic tumorigenesis.

Original languageEnglish (US)
Pages (from-to)14789-14794
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume99
Issue number23
DOIs
StatePublished - Nov 12 2002

ASJC Scopus subject areas

  • General

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