TY - JOUR
T1 - Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues
AU - Tumanov, Alexei V.
AU - Kuprash, Dmitry V.
AU - Lagarkova, Maria A.
AU - Grivennikov, Sergei I.
AU - Abe, Koichiro
AU - Shakhov, Alexander N.
AU - Drutskaya, Ludmila N.
AU - Stewart, Colin L.
AU - Chervonsky, Alexander V.
AU - Nedospasov, Sergei A.
N1 - Funding Information:
This project has been funded in part with U.S. Federal funds from the National Cancer Institute, National Institutes of Health (Contract N01-CO-12400) and by grants CA65795 from the National Institutes of Health and 02-04-49105a from the Russian Foundation for Basic Research. A.V.T. was supported by a research training fellowship from the International Agency for Research on Cancer. M.A.L. was supported by a postdoctoral fellowship from the Cancer Research Institute. S.A.N. is an International Research Scholar of the Howard Hughes Medical Institute.
PY - 2002/9/1
Y1 - 2002/9/1
N2 - In order to definitively ascertain the functional contribution of lymphotoxin (LT) expressed by B cells, we produced mice with the LTβ gene deleted from B cells (B-LTβ KO mice). In contrast to systemic LTβ deletion, in B-LTβ KO mice only splenic microarchitecture was affected, while lymph nodes and Peyer's patches (PP) were normal, except for PP's reduced size. Even though B-LTβ KO spleens retained a small number of follicular dendritic cells (FDC) which appeared to be dependent on LTβ produced by T cells, IgG responses to sheep red blood cells were markedly reduced. Thus, the organogenic function of B-LTβ is almost entirely restricted to spleen, where it supports the correct lymphoid architecture that is critical for an effective humoral immune response.
AB - In order to definitively ascertain the functional contribution of lymphotoxin (LT) expressed by B cells, we produced mice with the LTβ gene deleted from B cells (B-LTβ KO mice). In contrast to systemic LTβ deletion, in B-LTβ KO mice only splenic microarchitecture was affected, while lymph nodes and Peyer's patches (PP) were normal, except for PP's reduced size. Even though B-LTβ KO spleens retained a small number of follicular dendritic cells (FDC) which appeared to be dependent on LTβ produced by T cells, IgG responses to sheep red blood cells were markedly reduced. Thus, the organogenic function of B-LTβ is almost entirely restricted to spleen, where it supports the correct lymphoid architecture that is critical for an effective humoral immune response.
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U2 - 10.1016/S1074-7613(02)00397-7
DO - 10.1016/S1074-7613(02)00397-7
M3 - Article
C2 - 12354378
AN - SCOPUS:18644366772
SN - 1074-7613
VL - 17
SP - 239
EP - 250
JO - Immunity
JF - Immunity
IS - 3
ER -