Distinct distribution of rare US genotypes of Kaposi's sarcoma-associated herpesvirus (KSHV) in South Texas: Implications for KSHV epidemiology

Y. J. Zhang, T. L. Davis, X. P. Wang, J. H. Deng, J. Baillargeon, I. T. Yeh, H. B. Jenson, S. J. Gao

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Abstract

Genotypes of Kaposi's sarcoma (KS) - associated herpesvirus (KSHV) from patients with KS in South Texas were examined. Open-reading frame (ORF) - K1 and ORF-K15 DNA segments from 16 KSHV isolates were amplified by polymerase chain reaction, and KSHV subtypes were assigned on the basis of sequence variations. K1 genotyping showed that 75% exhibited C subtype and 25% exhibited A subtype. K15 genotyping showed that 56% exhibited M form, of which 89% exhibited C3 K1 subtype and 44% exhibited P form. A unique isolate was found and was classified as C6 clade. All of the M KSHV isolates had been obtained from human immunodeficiency virus-negative classic KS patients >50 years of age, of whom 78% were Hispanic. Conversely, all KS patients with AIDS were <36 years of age and exhibited P form KSHV. These findings indicate that C3/M KSHV genotypes are more prevalent in South Texas (50%) than in other US regions (3%) and that M form KSHV likely existed in this region long before the AIDS epidemic.

Original languageEnglish (US)
Pages (from-to)125-129
Number of pages5
JournalJournal of Infectious Diseases
Volume183
Issue number1
DOIs
StatePublished - 2001

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Human Herpesvirus 8
Epidemiology
Genotype
Kaposi's Sarcoma
Open Reading Frames
Acquired Immunodeficiency Syndrome
Hispanic Americans
HIV
Polymerase Chain Reaction
DNA

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Distinct distribution of rare US genotypes of Kaposi's sarcoma-associated herpesvirus (KSHV) in South Texas : Implications for KSHV epidemiology. / Zhang, Y. J.; Davis, T. L.; Wang, X. P.; Deng, J. H.; Baillargeon, J.; Yeh, I. T.; Jenson, H. B.; Gao, S. J.

In: Journal of Infectious Diseases, Vol. 183, No. 1, 2001, p. 125-129.

Research output: Contribution to journalArticle

Zhang, Y. J. ; Davis, T. L. ; Wang, X. P. ; Deng, J. H. ; Baillargeon, J. ; Yeh, I. T. ; Jenson, H. B. ; Gao, S. J. / Distinct distribution of rare US genotypes of Kaposi's sarcoma-associated herpesvirus (KSHV) in South Texas : Implications for KSHV epidemiology. In: Journal of Infectious Diseases. 2001 ; Vol. 183, No. 1. pp. 125-129.
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abstract = "Genotypes of Kaposi's sarcoma (KS) - associated herpesvirus (KSHV) from patients with KS in South Texas were examined. Open-reading frame (ORF) - K1 and ORF-K15 DNA segments from 16 KSHV isolates were amplified by polymerase chain reaction, and KSHV subtypes were assigned on the basis of sequence variations. K1 genotyping showed that 75{\%} exhibited C subtype and 25{\%} exhibited A subtype. K15 genotyping showed that 56{\%} exhibited M form, of which 89{\%} exhibited C3 K1 subtype and 44{\%} exhibited P form. A unique isolate was found and was classified as C6 clade. All of the M KSHV isolates had been obtained from human immunodeficiency virus-negative classic KS patients >50 years of age, of whom 78{\%} were Hispanic. Conversely, all KS patients with AIDS were <36 years of age and exhibited P form KSHV. These findings indicate that C3/M KSHV genotypes are more prevalent in South Texas (50{\%}) than in other US regions (3{\%}) and that M form KSHV likely existed in this region long before the AIDS epidemic.",
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