Disseminated phaeohyphomycosis: Review of an emerging mycosis

Sanjay G. Revankar, Jan E. Patterson, Deanna A. Sutton, Renee Pullen, Michael G. Rinaldi

Research output: Contribution to journalReview articlepeer-review

289 Scopus citations

Abstract

Disseminated phaeohyphomycosis is an uncommon infection caused by dematiaceous fungi, although the number of case reports about this infection has been increasing in recent years. A total of 72 cases are reviewed. Scedosporium prolificans is by far the most common cause. The presence of melanin in their cell walls may be a virulence factor for these fungi. The primary risk factor is decreased host immunity, although cases in apparently immunocompetent patients have been reported. Eosinophilia was seen in 11% of cases. Endocarditis is mostly reported on bioprosthetic valves, particularly those of porcine origin. The outcome of antifungal therapy remains poor, with an overall mortality rate of 79%. Special precautions taken for immunocompromised patients may help prevent exposure to fungi during the patients' period of greatest risk. The development of newer antifungal agents and combination therapy may hold promise in improving the management of these devastating infections in the future.

Original languageEnglish (US)
Pages (from-to)467-476
Number of pages10
JournalClinical Infectious Diseases
Volume34
Issue number4
DOIs
StatePublished - Feb 15 2002

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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