Dissection of promoter control modules that direct Bmp4 expression in the epithelium-derived components of hair follicles

Jianghong Zhang, Xiaoyu Tan, Christopher H. Contag, Yongbo Lu, Dayong Guo, Stephen E. Harris, Jian Q. Feng

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Bone morphogenetic protein 4 (Bmp4) plays a significant role in development. Using transgenic approaches, we studied the mechanisms controlling Bmp4 expression during primordial and mature tissue development, as well as in epithelium- and mesenchyme-derived components with hair follicles as a model. In this report, we demonstrated that the promoter region between the -0.26 and the -1.14 kb, highly conserved between human and mouse, controls Bmp4 expression in the epithelium-derived tissues but not in mesenchyme-derived tissues of hair follicles, suggesting that control modules for Bmp4 expression in epithelium-derived tissues and mesenchyme originated tissues are in separate regions. Using live embryos and mice, we demonstrated the temporal and spatial activities of these modules. We also demonstrated that control regions for Bmp4 expression in primordial and differentiated hair follicle tissues are separated. Therefore we present a model to explain a mechanism controlling expression of the Bmp4 gene in different tissue types, as well as different development stages as related to hair development.

Original languageEnglish (US)
Pages (from-to)1412-1419
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume293
Issue number5
DOIs
Publication statusPublished - Jan 1 2002

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Keywords

  • Bmp4
  • Development
  • Hair follicle
  • Promoter
  • Transgenic mice

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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