Dissecting the Processes of Aging Using the Nematode Caenorhabditis elegans

Samuel T. Henderson, Shane L. Rea, Thomas E. Johnson

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

Abstract

This chapter explains the process of aging using the nematode Caenorhabditis elegans. Molecular genetic analysis of aging in C. elegans begins with the startling discovery of the first gerontogene. C. elegans contains a large family of insulin-like sequences. The genes are frequently found in clusters and are derived likely from recent duplication events. The gene family shares roughly 25 to 40 percent amino acid identity, yet they all contain signatures of insulin-like molecules. Soil is the natural habitat of the free-living nematode C. elegans and when a food source is exhausted, or in response to other adverse conditions, an alternative developmental program called the dauer pathway is activated. The decision to suspend reproductive development and instead become a long-lived, growth-arrested dauer is made at the first larval stage (L1). Adverse conditions are sensed by chemosensory and thermosensitive mechanisms, whereas overcrowding is detected by the local concentration of a lipid soluble pheromone secreted by L1 animals. Modulating DAF-16 transcriptional activity is a major function of insulin signaling in C. elegans, and nuclear localized DAF-16 plays a necessary role in increased longevity.

Original languageEnglish (US)
Title of host publicationHandbook of the Biology of Aging
PublisherElsevier Inc.
Pages360-399
Number of pages40
ISBN (Print)9780120883875
DOIs
StatePublished - Dec 1 2005

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Henderson, S. T., Rea, S. L., & Johnson, T. E. (2005). Dissecting the Processes of Aging Using the Nematode Caenorhabditis elegans. In Handbook of the Biology of Aging (pp. 360-399). Elsevier Inc.. https://doi.org/10.1016/B978-012088387-5/50016-9