Disinhibition of the dorsomedial hypothalamus increases the frequency of augmented breaths in the anesthetized rat

C. R. Reynolds, K. Vujisic, P. W. Davenport, L. F. Hayward

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

The present study was undertaken to identify if activation of the dorsomedial hypothalamus (DMH) elicits augmented breaths (ABs). DMH disinhibition in urethane anesthetized rats produced both an increase in baseline respiratory rate (RR) and an increase in the number of ABs. The increase in RR was associated with a decrease in both the time of inspiration (Ti) and expiration (Te) and the peak change in RR was observed 5 min post DMH activation. In contrast, the increase in ABs was greatest during the first 1.25 min, and both Tis of the ABs did not change significantly from pre-injection values. The Te of the ABs did decrease but remained significantly greater than the Te of the normal breath during DMH disinhibition. Our results support the hypothesis that the central neural pathway involved in the maintenance of normal respiratory pattern may be distinct from pathways involved in the generation of ABs.

Original languageEnglish (US)
Title of host publicationIntegration in Respiratory Control
Subtitle of host publicationFrom Genes to Systems
EditorsMarc Poulin, Richard Wilson
Pages274-278
Number of pages5
DOIs
StatePublished - 2008
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume605
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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